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Titolo:
SUBLETHAL OXYGEN-GLUCOSE DEPRIVATION ALTERS HIPPOCAMPAL NEURONAL AMPARECEPTOR EXPRESSION AND VULNERABILITY TO KAINATE-INDUCED DEATH
Autore:
YING HS; WEISHAUPT JH; GRABB M; CANZONIERO LMT; SENSI SL; SHELINE CT; MONYER H; CHOI DW;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT NEUROL,660 S EUCLID AVE ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT NEUROL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,CTR STUDY NERVOUS SYST INJURY ST LOUIS MO 63110 UNIV HEIDELBERG,ZMBH,CTR MOL BIOL D-69120 HEIDELBERG GERMANY
Titolo Testata:
The Journal of neuroscience
fascicolo: 24, volume: 17, anno: 1997,
pagine: 9536 - 9544
SICI:
0270-6474(1997)17:24<9536:SODAHN>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICAL CELL-CULTURE; METHYL-D-ASPARTATE; TRANSIENT FOREBRAIN ISCHEMIA; GLUTAMATE-OPERATED CHANNELS; GLOBAL CEREBRAL-ISCHEMIA; GENE-EXPRESSION; PROTEIN-SYNTHESIS; GERBIL HIPPOCAMPUS; MESSENGER-RNAS; CALCIUM PERMEABILITY;
Keywords:
GLUTAMATE RECEPTOR REGULATION; GLUR-D; SINGLE CELL RT-PCR; CALCIUM ACCUMULATION; ISCHEMIA; NEURONAL VULNERABILITY;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
87
Recensione:
Indirizzi per estratti:
Citazione:
H.S. Ying et al., "SUBLETHAL OXYGEN-GLUCOSE DEPRIVATION ALTERS HIPPOCAMPAL NEURONAL AMPARECEPTOR EXPRESSION AND VULNERABILITY TO KAINATE-INDUCED DEATH", The Journal of neuroscience, 17(24), 1997, pp. 9536-9544

Abstract

Recent studies have suggested that rats subjected to transient globalbrain ischemia develop depressed expression of GluR-B in CA1 hippocampal neurons. The present study was performed to determine whether a similar change in AMPA receptor expression could be triggered in vitro by sublethal oxygen-glucose deprivation in rat hippocampal neuronal cultures. mRNA was extracted from individual hippocampal neurons via patch electrodes and amplified by RT-PCR 24-48 hr after sublethal oxygen-glucose deprivation. Compared with controls, insulted neurons expressedincreased levels of GluR-D flop. As an indication that this change inreceptor expression was functionally significant, insulted cultures exhibited increased AMPA- or kainate-induced Ca-45(2+) accumulation sensitive to Joro spider toxin and increased vulnerability to kainate-induced death. These data support the hypothesis that exposure to ischemia may enhance subsequent hippocampal neuronal vulnerability to AMPA receptor-mediated excitotoxicity by modifying the relative expression ofAMPA receptor subunits in a manner that promotes Ca2+ permeability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 11:17:23