Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SOLUBLE E-SELECTIN AND INTERCELLULAR-ADHESION MOLECULE-1 PLASMA-LEVELS INCREASE DURING ACUTE MYOCARDIAL-INFARCTION
Autore:
PELLEGATTA F; PIZZETTI G; LU Y; RADAELLI A; POMES D; CARLINO M; MELONI C; BELOTTI G; GALLI L; VIDAL MJ; CHIERCHIA SL;
Indirizzi:
SAN RAFFAELE SCI INST,DEPT CARDIOL,LAB CARDIOVASC PATHOPHYSIOL,VIA OLGETTINA 60 I-20132 MILAN ITALY SAN RAFFAELE SCI INST,DEPT EPIDEMIOL I-20132 MILAN ITALY
Titolo Testata:
Journal of cardiovascular pharmacology
fascicolo: 4, volume: 30, anno: 1997,
pagine: 455 - 460
SICI:
0160-2446(1997)30:4<455:SEAIMP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; HUMAN VASCULAR ENDOTHELIUM; MONOCLONAL-ANTIBODY; REPERFUSION INJURY; SIALYL-LEX; ICAM-1; CELLS; INTERLEUKIN-1; NEUTROPHIL; ELAM-1;
Keywords:
SOLUBLE E-SELECTIN; SOLUBLE ICAM-1; MYOCARDIAL INFARCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
F. Pellegatta et al., "SOLUBLE E-SELECTIN AND INTERCELLULAR-ADHESION MOLECULE-1 PLASMA-LEVELS INCREASE DURING ACUTE MYOCARDIAL-INFARCTION", Journal of cardiovascular pharmacology, 30(4), 1997, pp. 455-460

Abstract

Previous studies have shown that adhesion molecules play a crucial role in leukocyte-endothelium interactions that occur during myocardial ischemia and reperfusion. We assessed the plasma levels of the solubleform of E-selectin (sE-selectin) and intercellular adhesion molecule-1 (sICAM-1) in 15 patients with acute myocardial infarction (AMI) and in 15 controls with chronic stable angina. In patients with AMI, the levels of sE-selectin and sICAM-1 increased significantly during the first 8 h after infarction and subsequently decreased. Soluble E-selectin levels were inversely related to the peak plasma levels of creatine kinase-MB (CK-MB), and the time course of their appearance in plasma correlated with that of neutrophil count and plasma D-dimer. In individual patients, peak and mean sICAM-1 levels correlated respectively with plasma D-dimer concentrations and monocyte count, but no correlationwere found when their time courses were analyzed. Eight hours after symptom onset, the mean plasma sE-selectin levels were higher in patients with AMI than in those with stable angina, whereas no significant differences were found in mean plasma sICAM-1 levels between the two groups at every time analyzed. In the acute phase of MI (a) sE-selectin and sICAM-1 levels increase during the first 8 h and subsequently decrease; (b) the increase in sE-selectin probably reflects activation of endothelial cells, correlates with other inflammatory and coagulation parameters, and is inversely related to the degree of myocardial damage; and (c) sICAM-1 plasma levels do not represent a good marker of ''cell activation'' because they reflect activation of different cells and may be affected by different conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 17:03:47