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Titolo:
EFFECT OF SUPEROXIDE ANIONS ON RED-BLOOD-CELL RHEOLOGIC PROPERTIES
Autore:
BASKURT OK; TEMIZ A; MEISELMAN HJ;
Indirizzi:
UNIV SO CALIF,SCH MED,DEPT PHYSIOL & BIOPHYS,1333 SAN PABLO ST,MMR 626 LOS ANGELES CA 90033 UNIV SO CALIF,SCH MED,DEPT PHYSIOL & BIOPHYS LOS ANGELES CA 90033
Titolo Testata:
Free radical biology & medicine
fascicolo: 1, volume: 24, anno: 1998,
pagine: 102 - 110
SICI:
0891-5849(1998)24:1<102:EOSAOR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXYGEN FREE-RADICALS; HYDROGEN-PEROXIDE; MEMBRANE-PROTEINS; ERYTHROCYTE AGGREGATION; LIPID-PEROXIDATION; OXIDATIVE STRESS; DEFORMABILITY; SURFACE; DAMAGE; PATHOPHYSIOLOGY;
Keywords:
SUPEROXIDE; OXIDANT STRESS; RED BLOOD CELL AGGREGATION; RED BLOOD DEFORMABILITY; HEMORHEOLOGY; ISCHEMIA-REPERFUSION; NO-REFLOW PHENOMENA; FREE RADICALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
O.K. Baskurt et al., "EFFECT OF SUPEROXIDE ANIONS ON RED-BLOOD-CELL RHEOLOGIC PROPERTIES", Free radical biology & medicine, 24(1), 1998, pp. 102-110

Abstract

The human red blood cell (RBC) is known to be susceptible to oxidant damage, with both structural and functional properties altered consequent to oxidant attack. Such oxidant-related alterations may lead to changes of RBC theologic behavior (i.e., deformability, aggregability). Two different models of oxidant stress were used in this study to generate superoxide anions either internal or external to the RBC. Our results indicate that generation of superoxide within the RBC by phenazine methosulfate decreases RBC deformability without effects on cell aggregation. Conversely, superoxide generated externally by the xanthine oxidase-hypoxanthine system primarily affects RBC aggregability: the shear rate necessary to disaggregate RBC was markedly increased while the extent of aggregation decreased slightly. Increased disaggregation shear rate (i.e., greater aggregate strength) as a result of superoxide radical damage may adversely affect the dynamics of blood flow in low-shear portions of the circulation, and may also play a role in the no-reflow phenomena encountered after ischemia-reperfusion. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 23:28:01