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Titolo:
EARLY EXPRESSION OF INTERLEUKIN-12, P40 SUBUNIT AND IFN-GAMMA INHIBITS REGRESSION OF AK-5 TUMOR
Autore:
NANDAKUMAR KS; KUMARI AL; KHAR A;
Indirizzi:
CTR CELLULAR & MOL BIOL HYDERABAD 500007 ANDHRA PRADESH INDIA CTR CELLULAR & MOL BIOL HYDERABAD 500007 ANDHRA PRADESH INDIA
Titolo Testata:
Cytokines cellular & molecular therapy
fascicolo: 4, volume: 3, anno: 1997,
pagine: 225 - 232
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; SPONTANEOUS IMMUNOLOGICAL REGRESSION; INTERFERON-GAMMA; RAT HISTIOCYTOMA; NECROSIS-FACTOR; CYTOKINE; ANTIGEN; IL-12; ERADICATION; LYMPHOCYTES;
Keywords:
TH1 CYTOKINES; TUMOR REGRESSION;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
K.S. Nandakumar et al., "EARLY EXPRESSION OF INTERLEUKIN-12, P40 SUBUNIT AND IFN-GAMMA INHIBITS REGRESSION OF AK-5 TUMOR", Cytokines cellular & molecular therapy, 3(4), 1997, pp. 225-232

Abstract

Differential immune response of syngeneic animals to a rat histiocytoma AK-5 based on the route of transplantation was investigated. Spontaneous regression of subcutaneous tumor was observed in 55-60% of animals. On the other hand, when the tumor cells were injected intraperitoneally, none of the animals survived. Earlier studies from this laboratory indicated upregulation of Th-l-type cytokines, leading to early tumor regression when the tumor was transplanted subcutaneously. Hence we evaluated and compared the circulatory-cytokine profiles in both s.c. and i.p. tumor-injected animals. Our results show an early increase in the p40 subunit of IL-12, prolific increase in IFN-gamma and lower levels of IL-2 in i.p. tumor-injected animals. However, there were no significant differences in the levels of transcripts for these cytokines in either of the groups. Significantly, a lower level of cytotoxicity was observed with splenocytes from i.p. tumor-transplanted animals. Moreover, the cytotoxicity of IL-12-activated but not IL-2-activated NK cells was inhibited by sera (rich in IL-12, p40 subunit) from i.p. tumor-transplanted animals, suggesting the participation of p40 subunit in the regulation of tumor regression. Thus the present study suggests a possible translational regulation of Th-1-type cytokines in AK-5 tumor-host interaction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 20:07:33