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Titolo:
PERFLUBRON DECREASES INFLAMMATORY CYTOKINE PRODUCTION BY HUMAN ALVEOLAR MACROPHAGES
Autore:
THOMASSEN MJ; BUHROW LT; WIEDEMANN HP;
Indirizzi:
CLEVELAND CLIN FDN,DEPT PULM & CRIT CARE MED,9500 EUCLID AVE,DESK A90CLEVELAND OH 44195 CLEVELAND CLIN FDN,DEPT IMMUNOL CLEVELAND OH 44195
Titolo Testata:
Critical care medicine
fascicolo: 12, volume: 25, anno: 1997,
pagine: 2045 - 2047
SICI:
0090-3493(1997)25:12<2045:PDICPB>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS SYNDROME; NF-KAPPA-B; SYNTHETIC SURFACTANT EXOSURF; TUMOR-NECROSIS-FACTOR; GAS-EXCHANGE; LIQUID VENTILATION; SEPTIC SHOCK; IMPROVEMENT; ACTIVATION; TYLOXAPOL;
Keywords:
PERFLUBRON; TUMOR NECROSIS FACTOR; INTERLEUKIN-1; INTERLEUKIN 6; HUMAN ALVEOLAR MACROPHAGES; ENDOTOXIN; ADULT RESPIRATORY DISTRESS SYNDROME; CYTOKINE; BRONCHOALVEOLAR LAVAGE; ANTIINFLAMMATORY; PARTIAL LIQUID VENTILATION;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Thomassen et al., "PERFLUBRON DECREASES INFLAMMATORY CYTOKINE PRODUCTION BY HUMAN ALVEOLAR MACROPHAGES", Critical care medicine, 25(12), 1997, pp. 2045-2047

Abstract

Objective: To determine whether inflammatory cytokine production by stimulated human alveolar macrophages is affected by perflubron exposure. Design: Controlled laboratory investigation of alveolar macrophage function in vitro, Setting: Research laboratory, Subjects: Cultured alveolar macrophages obtained by bronchoalveolar lavage from eleven normal volunteers. interventions: Endotoxin stimulated alveolar macrophages were treated with perflubron. Measurements and Main Results: Alveolar macrophages were stimulated for 1 hr with lipopolysaccharide and then treated with perflubron for 23 hrs. Cell free supernatants were collected and cytokines were assayed by enzyme-linked immunosorbent assay. Tumor necrosis factor-alpha, interleukin-l, and interleukin-g were stimulated by lipopolysaccharide (endotoxin) and all of these cytokines were significantly (p <.05) inhibited by perflubron. Cell viability was not affected by perflubron, Basal cytokine concentrations from unstimulated alveolar macrophages were not altered by perflubron. Conclusions: Exposure of stimulated human alveolar macrophages to perflubron invitro decreases cytokine production. This observation suggests that perflubron may have anti-inflammatory activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:27:29