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Titolo:
EFFECT OF P-450 INHIBITORS ON BENZYLISOQUINOLINE ALKALOID BIOSYNTHESIS IN CULTURED ROOTS OF STEPHANIA-CEPHARANTHA AND MENISPERMUM-DAURICUM
Autore:
SUGIMOTO Y; UCHIDA S; INANAGA S; ISOGAI A;
Indirizzi:
TOTTORI UNIV,ARID LAND RES CTR,1390 HAMASAKA TOTTORI 680 JAPAN NARA INST SCI & TECHNOL NARA 63001 JAPAN
Titolo Testata:
Journal of plant physiology
fascicolo: 4, volume: 150, anno: 1997,
pagine: 376 - 380
SICI:
0176-1617(1997)150:4<376:EOPIOB>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOCHROME-P-450 ENZYME; BERBERIS-STOLONIFERA;
Keywords:
MENISPERMUM DAURICUM DC; STEPHANIA CEPHARANTHA HAYATA; ACUTUMINE; DAURICINE; KETOCONAZOLE; P-450 INHIBITOR; TYRAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
Y. Sugimoto et al., "EFFECT OF P-450 INHIBITORS ON BENZYLISOQUINOLINE ALKALOID BIOSYNTHESIS IN CULTURED ROOTS OF STEPHANIA-CEPHARANTHA AND MENISPERMUM-DAURICUM", Journal of plant physiology, 150(4), 1997, pp. 376-380

Abstract

The effect of cytochrome P-450 inhibitors on biosynthesis of benzylisoquinoline alkaloids, in cultured roots of Stephania cepharantha Hayata and Menispermum dauricum DC., was studied. In S. cepharantha only two alkaloids, aromoline and berbamine, were produced. Most inhibitors reduced root growth and alkaloid biosynthesis. Alkaloid contents were positively correlated with root growth (r = 0.82 and 0.78 for aromolineand berbamine, respectively). In M. dauricum ancymidol and metyraponepromoted root growth, ketoconazole was inhibitory, while other inhibitors had inconsistent effects. production of the alkaloids dauricine and acutumine was curtailed by all inhibitors. Alkaloid contents were not related to root growth. None of the inhibitors induced accumulationof the immediate monomeric precursors of bisbenzylisoquinoline. However, ketoconazole-treated M. dauricum roots accumulated tyramine, an early precursor of benzylisoquinoline, and two unidentified tyrosine-derived alkaloids with molecular masses of 353 and 426.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 08:39:06