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Titolo:
IDENTIFICATION OF SPECIFIC AMINO-ACID-RESIDUES OF ADENOVIRUS-12 E1A INVOLVED IN TRANSFORMATION AND P300 BINDING
Autore:
SAWADA Y; ISHINO M; MIURA K; OHTSUKA E; FUJINAGA K;
Indirizzi:
SAPPORO MED UNIV,SCH MED,CANC RES INST SAPPORO HOKKAIDO 060 JAPAN HOKKAIDO UNIV,FAC PHARMACEUT SCI SAPPORO HOKKAIDO 060 JAPAN KANSAI RES INST,KYOTO RES PK SCI CTR,SHIMOGYO KU KYOTO 600 JAPAN TAKARA SHAZO CO LTD,BIOMED GRP SHIGA 525 JAPAN
Titolo Testata:
Virus genes
fascicolo: 2, volume: 15, anno: 1997,
pagine: 161 - 170
SICI:
0920-8569(1997)15:2<161:IOSAOA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINOBLASTOMA GENE-PRODUCT; TRANSCRIPTION FACTOR; MOLECULAR-CLONING; COMPLEX-FORMATION; SUSCEPTIBILITY GENE; MUTATIONAL ANALYSIS; FUNCTIONAL DOMAINS; CELLULAR PROTEINS; DNA-SYNTHESIS; 2 DISTINCT;
Keywords:
ADENOVIRUS TYPE 12; E1A; TRANSFORMATION; P300 BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
Y. Sawada et al., "IDENTIFICATION OF SPECIFIC AMINO-ACID-RESIDUES OF ADENOVIRUS-12 E1A INVOLVED IN TRANSFORMATION AND P300 BINDING", Virus genes, 15(2), 1997, pp. 161-170

Abstract

The early region 1A (E1A) gene of highly oncogenic adenovirus type 12(Ad12) was analyzed for transforming activity and protein binding using specific mutations, The Ad12 E1A proteins were found to bind p300 protein mainly within the CR1 region, although mutations that affect both p300 binding and transformation were identified in both the CR1 andthe N-terminal region. The most critical mutation dlf89 located in the CR1 region was further dissected by point mutations and the results identified S-68 as the most critical for transformation and E-67 as the most critical for p300 binding. Specific mutations that retain p300 binding but impair transcriptional repression of a viral enhancer werealso identified in both the N-terminal and CR1 regions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 05:45:58