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Titolo:
PERIPHERAL NOXIOUS-STIMULATION RELEASES SPINAL PGE2 DURING THE FIRST-PHASE IN THE FORMALIN ASSAY OF THE RAT
Autore:
SCHEUREN N; NEUPERT W; IONAC M; NEUHUBER W; BRUNE K; GEISSLINGER G;
Indirizzi:
UNIV ERLANGEN NURNBERG,DEPT EXPT & CLIN PHARMACOL & TOXICOL,UNIV STR 22 D-91054 ERLANGEN GERMANY UNIV ERLANGEN NURNBERG,DEPT ANAT D-91054 ERLANGEN GERMANY
Titolo Testata:
Life sciences
fascicolo: 21, volume: 60, anno: 1997,
pagine: 295 - 300
SICI:
0024-3205(1997)60:21<295:PNRSPD>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Keywords:
PROSTAGLANDIN E-2; MICRODIALYSIS; SPINAL CORD; FORMALIN ASSAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
N. Scheuren et al., "PERIPHERAL NOXIOUS-STIMULATION RELEASES SPINAL PGE2 DURING THE FIRST-PHASE IN THE FORMALIN ASSAY OF THE RAT", Life sciences, 60(21), 1997, pp. 295-300

Abstract

Injection of formalin (5%; 50 mu l) into the dorsal surface of the hind paw of rats evoked a characteristic biphasic flinching behaviour ofthe injured paw accompanied by a significant increase in the interstitial prostaglandin E2 (PGE2) concentration of the dorsal lumbar spinalcord, Interestingly, the increase in PGE2 concentration was only observed during the first phase of the formalin behavioural response (during the 0-10 and 10-20 min microdialysis-sample). Saline paw injection did not have a significant effect on behaviour or on PGE2 concentration, These data suggest that spinal release of PGE2 is involved in nociceptive processing in the formalin-induced hyperalgesia model of the rat during the first but not second phase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 21:00:31