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Titolo:
EFFECTS OF AMPHETAMINE CHALLENGE ON LOCAL CEREBRAL GLUCOSE-UTILIZATION AFTER CHRONIC DOPAMINE D-1 AND D-2 RECEPTOR AGONIST ADMINISTRATION TO RATS
Autore:
HUANG YH; TSAI SJ; HUANG HJ; SIM CB;
Indirizzi:
NATL YANG MING UNIV,INST ANAT TAIPEI 112 TAIWAN NATL YANG MING UNIV,DEPT ANAT TAIPEI 112 TAIWAN VET GEN HOSP,DEPT PSYCHIAT TAIPEI 11217 TAIWAN NATL YANG MING UNIV,SCH MED,DIV NEUROPSYCHIAT TAIPEI 112 TAIWAN NATL YANG MING UNIV,CEREBRAL METAB LAB TAIPEI 112 TAIWAN
Titolo Testata:
European journal of pharmacology
fascicolo: 2, volume: 338, anno: 1997,
pagine: 117 - 121
SICI:
0014-2999(1997)338:2<117:EOACOL>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
BEHAVIORAL SENSITIZATION; STIMULATION; EXPRESSION; QUINPIROLE; SKF-38393; BRAIN; D1;
Keywords:
AMPHETAMINE ADMINISTRATION, CHRONIC; DEOXYGLUCOSE; SENSITIZATION; SKF 38393; QUINPIROLE;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
Y.H. Huang et al., "EFFECTS OF AMPHETAMINE CHALLENGE ON LOCAL CEREBRAL GLUCOSE-UTILIZATION AFTER CHRONIC DOPAMINE D-1 AND D-2 RECEPTOR AGONIST ADMINISTRATION TO RATS", European journal of pharmacology, 338(2), 1997, pp. 117-121

Abstract

Repeated amphetamine administration can cause an augmentation of regional cerebral metabolic activity. This study analyzed the regional cerebral metabolic changes which occurred in rats after pretreatment withthe selective dopamine D-1 and D-2 receptor agonists, (+/-)SKF 38393 tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine HCl) and quinpirole(trans-(-)-4aR-4,4a,5,6,7,8,8a,9- -octahydro-5-propyl-1H-pyrazolo(3,4-g)quinoline), as measured by the 2-[C-14]deoxyglucose method. The results showed selective metabolic augmentation in rats pretreated with SKF 38393 but not in those pretreated with quinpirole alone or with quinpirole in combination with SKF 38393, These findings demonstrated that dopamine D, receptors may play a critical role in the development ofmetabolic augmentation after repeated stimulant administration. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:07:26