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Titolo:
AGENTS THAT BLOCK FIBRONECTIN FRAGMENT-MEDIATED CARTILAGE DAMAGE ALSOPROMOTE REPAIR
Autore:
HOMANDBERG GA; WEN C; HUI F;
Indirizzi:
RUSH PRESBYTERIAN ST LUKES MED CTR,RUSH MED COLL,DEPT BIOCHEM,1653 W CONGRESS PKWY CHICAGO IL 60612
Titolo Testata:
Inflammation research
fascicolo: 11, volume: 46, anno: 1997,
pagine: 467 - 471
SICI:
1023-3830(1997)46:11<467:ATBFFC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; MN-SUPEROXIDE DISMUTASE; GROWTH FACTOR-I; ARTICULAR CHONDROCYTES; HYDROGEN-PEROXIDE; EXPRESSION; CHONDROLYSIS; INTERLEUKIN-1; RELEASE; PROTEIN;
Keywords:
FIBRONECTIN; FIBRONECTIN FRAGMENTS; CARTILAGE; INTERLEUKIN-1; INSULIN-LIKE GROWTH FACTOR;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
G.A. Homandberg et al., "AGENTS THAT BLOCK FIBRONECTIN FRAGMENT-MEDIATED CARTILAGE DAMAGE ALSOPROMOTE REPAIR", Inflammation research, 46(11), 1997, pp. 467-471

Abstract

Objective and Design: The objective was to determine if agents that suppress catabolism might also enhance repair of irreversibly damaged cartilage. Material: Articular cartilage from bovine metacarpophalangeal joints was studied in explant culture. Treatment: Fibronectin fragments or IL-1 alpha, which potently cause proteoglycan (PG) loss from cartilage, were added to cultures also containing the catabolism-blocking agents: insulin-like growth factor-1, or N-acetylcysteine, or Arg-Gly-Asp-Ser peptide, and the effects of these agents on blocking PG lossdetermined. To test for repair or restoration of PG, cartilage was first damaged, damage agents removed and inhibitory agents added. Methods: Each mean and SD value for cartilage PG content was determined by assays of papain digests of cartilage from three similar cultures. Results: The agents either partially or fully blocked PG loss and promotedrepair. Conclusions: Normally irreversible cartilage damage was reversed by slowing ongoing catabolic processes during attempted repair. Thus, catabolic inhibitors have reparative potential.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 06:02:33