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Titolo:
D2 DOPAMINE-RECEPTOR GENE (DRD2) TAQ1-A POLYMORPHISM - REDUCED DOPAMINE D2 RECEPTOR-BINDING IN THE HUMAN STRIATUM ASSOCIATED WITH THE A1 ALLELE
Autore:
THOMPSON J; THOMAS N; SINGLETON A; PIGGOTT M; LLOYD S; PERRY EK; MORRIS CM; PERRY RH; FERRIER IN; COURT JA;
Indirizzi:
MRC,NEUROCHEM PATHOL UNIT NEWCASTLE TYNE NE4 6BE TYNE & WEAR ENGLAND MRC,NEUROCHEM PATHOL UNIT NEWCASTLE TYNE NE4 6BE TYNE & WEAR ENGLAND NEWCASTLE GEN HOSP,DEPT NEUROPATHOL NEWCASTLE TYNE NE4 6BE TYNE & WEAR ENGLAND ROYAL VICTORIA INFIRM,DEPT PSYCHIAT NEWCASTLE TYNE NE1 4LP TYNE & WEAR ENGLAND
Titolo Testata:
Pharmacogenetics
fascicolo: 6, volume: 7, anno: 1997,
pagine: 479 - 484
SICI:
0960-314X(1997)7:6<479:DDG(TP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEWY BODY DEMENTIA; NEUROLEPTIC SENSITIVITY; PARKINSONS-DISEASE; SENILE DEMENTIA; ALCOHOLISM; LOCUS; RFLP; LINKAGE; SMOKING; ABUSE;
Keywords:
CORPUS STRIATUM; DOPAMINE D2 RECEPTOR; DRD2 TAQ1 A POLYMORPHISM; HUMAN;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
J. Thompson et al., "D2 DOPAMINE-RECEPTOR GENE (DRD2) TAQ1-A POLYMORPHISM - REDUCED DOPAMINE D2 RECEPTOR-BINDING IN THE HUMAN STRIATUM ASSOCIATED WITH THE A1 ALLELE", Pharmacogenetics, 7(6), 1997, pp. 479-484

Abstract

The relationship between a dopamine D2 receptor genetic polymorphism at the Taq1 A locus and the level of D2 receptor binding was investigated in normal, middle aged to elderly subjects with no psychiatric or neurological disorders. D2 receptor binding was measured by autoradiography in the caudate, putamen and nucleus accumbens, using the specific D2 receptor ligand [H-3]-raclopride. In a sample of 44 individuals, only one was homozygous for the A1 allele, 25 were homozygous for A2 and 18 were heterozygotes. The presence of one or two A1 alleles was associated with reduced D2 receptor binding in all areas of the striatum, reaching statistical significance in the ventral caudate and putamen(p = 0.01 and p = 0.044, respectively). This reduction was more marked in males than females, particularly in the putamen. A genetic predisposition to lower D2 receptor expression may increase susceptibility to neuroleptic medication or clinical symptoms that are associated withdiseases involving dopaminergic pathology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 07:14:40