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Titolo:
MORTALITY OVER 4 YEARS IN SHEP PARTICIPANTS WITH A LOW ANKLE-ARM INDEX
Autore:
NEWMAN AB; TYRRELL KS; KULLER LH;
Indirizzi:
UNIV PITTSBURGH,DIV GERIATR MED,DEPT MED,3520 5TH AVE,KEYSTONE BLDG,SUITE 300 PITTSBURGH PA 15213 UNIV PITTSBURGH,GRAD SCH PUBL HLTH PITTSBURGH PA 15213
Titolo Testata:
Journal of the American Geriatrics Society
fascicolo: 12, volume: 45, anno: 1997,
pagine: 1472 - 1478
SICI:
0002-8614(1997)45:12<1472:MO4YIS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL ARTERIAL-DISEASE; CORONARY-HEART-DISEASE; BLOOD-PRESSURE INDEX; CARDIOVASCULAR-DISEASE; RISK FACTOR; POPULATION; ATHEROSCLEROSIS; WOMEN; PREVALENCE; MORBIDITY;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
A.B. Newman et al., "MORTALITY OVER 4 YEARS IN SHEP PARTICIPANTS WITH A LOW ANKLE-ARM INDEX", Journal of the American Geriatrics Society, 45(12), 1997, pp. 1472-1478

Abstract

OBJECTIVES: To assess the risk of total and cardiovascular mortality in older adults with systolic hypertension and with a low ankle-arm index (AAI) as a marker of subclinical peripheral arterial disease (PAD). DESIGN: Prospective observational study PARTICIPANTS: A subgroup of 1537 participants in the Systolic Hypertension in the Elderly Program (SHEP) were screened for lower extremity arterial disease using the AAI. Participants were evaluated at 4 years to determine vital status and cause of death. Total and cardiovascular disease (CVD) mortality rates were assessed in relationship to clinical CVD at baseline, cardiovascular risk factors and the presence of a low AAI (subclinical PAD). RESULTS: Total mortality rates increased as the AAI decreased in those with and without clinical CVD at baseline. In those without clinical CVD at baseline, the presence of an AAI less than or equal to .9 was associated with an age-adjusted relative risk (RR) of 3.00 for total mortality in men and 2.67 in women. Results were similar for CVD mortality and persisted after adjustment for cardiovascular risk factors including the presence of an abnormal electrocardiogram. CONCLUSIONS: A lowankle arm-index predicted a two to three-fold increase in total and cardiovascular mortality in older adults with systolic hypertension of risk for incident cardiovascular disease. In this study of older adults with systolic hypertension, 19.7% of the participants had subclinical PAD. Risk factor modification could be targeted to older adults based on markers of asymptomatic atherosclerosis.

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Documento generato il 24/11/20 alle ore 10:22:50