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Titolo:
THE ASSOCIATION OF ANTIHYPERTENSIVE AGENTS WITH MRI WHITE-MATTER FINDINGS AND WITH MODIFIED MINI-MENTAL-STATE-EXAMINATION IN OLDER ADULTS
Autore:
HECKBERT SR; LONGSTRETH WT; PSATY BM; MURROS KE; SMITH NL; NEWMAN AB; WILLIAMSON JD; BERNICK C; FURBERG CD;
Indirizzi:
CARDIOVASC HLTH STUDY COORDINATING CTR,1501 4TH AVE,SUITE 2105 SEATTLE WA 98101 UNIV WASHINGTON,CARDIOVASC HLTH RES UNIT,DEPT EPIDEMIOL SEATTLE WA 98195 UNIV WASHINGTON,DEPT MED SEATTLE WA 98195 UNIV WASHINGTON,DEPT HLTH SERV SEATTLE WA 98195 UNIV WASHINGTON,DEPT NEUROL SEATTLE WA 98195 UNIV KUOPIO,DEPT NEUROL FIN-70211 KUOPIO FINLAND WAKE FOREST UNIV,BOWMAN GRAY SCH MED,STROKE CTR WINSTON SALEM NC 00000 UNIV PITTSBURGH,DEPT MED PITTSBURGH PA 15260 JOHNS HOPKINS UNIV,DEPT MED BALTIMORE MD 21218 UNIV CALIF DAVIS,DEPT MED DAVIS CA 00000 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI WINSTON SALEMNC 27103
Titolo Testata:
Journal of the American Geriatrics Society
fascicolo: 12, volume: 45, anno: 1997,
pagine: 1423 - 1433
SICI:
0002-8614(1997)45:12<1423:TAOAAW>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; CEREBROVASCULAR RISK-FACTORS; CARDIOVASCULAR HEALTH; COGNITIVE FUNCTION; BRAIN-BARRIER; HYPERTENSIVE SUBJECTS; LOOP DIURETICS; LESIONS; ABNORMALITIES; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
S.R. Heckbert et al., "THE ASSOCIATION OF ANTIHYPERTENSIVE AGENTS WITH MRI WHITE-MATTER FINDINGS AND WITH MODIFIED MINI-MENTAL-STATE-EXAMINATION IN OLDER ADULTS", Journal of the American Geriatrics Society, 45(12), 1997, pp. 1423-1433

Abstract

OBJECTIVES: To examine the association of antihypertensive regimen with magnetic resonance imaging (MRI) white matter hyperintensity and with cognitive impairment in older adults. DESIGN: Cross-sectional study. SETTING: The Cardiovascular Health study, an observational prospective cohort study of risk factors for coronary heart disease and stroke in men and women 65 years of age and older. PARTICIPANTS: 1268 men andwomen with pharmacologically treated hypertension. MEASUREMENTS: Information on medication use, medical history, and health habits was collected at clinic examinations. Participants completed the Modified Mini-Mental State Examination (3MS) and underwent MRI examination. Withoutclinical information, study neuroradiologists assigned an overall grade of white matter signal intensity on MRI on a scale from 0 (no findings) to 9 (extensive findings). RESULTS: Adjusted mean white matter grade was higher for users of calcium channel blockers (2.59, P = .007) and users of loop diuretics (2.60, P = .015) than for users of beta blockers (2.12). The association was present for both dihydropyridine and non-dihydropyridine calcium channel blockers. Adjusted mean 3MS scores were lower for users of calcium channel blockers (89.6, P < .002), especially dihydropyridines, and users of loop diuretics (89.7, P < .006) than for users of beta blockers (92.3). No statistically significant association could be shown for users of other drug regimens, including thiazides and ACE inhibitors. CONCLUSION: In this study, users of antihypertensive regimens which included calcium channel blockers or loop diuretics had more severe white matter hyperintensity on MRI and worse performance on 3MS than users of beta blockers.

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Documento generato il 25/11/20 alle ore 15:47:39