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Titolo:
GRANULOCYTE-COLONY-STIMULATING FACTOR GIVEN IN ADDITION TO INTERFERON-ALPHA TO MOBILIZE PERIPHERAL-BLOOD STEM-CELLS FOR AUTOLOGOUS TRANSPLANTATION IN CHRONIC MYELOID-LEUKEMIA
Autore:
ARCHIMBAUD E; MICHALLET M; PHILIP I; CHARRIN C; CLAPISSON G; BELHABRI A; GUILHOT F; STRYCKMANS P; ADELEINE P; FIERE D;
Indirizzi:
HOP EDOUARD HERRIOT,SERV HEMATOL F-69437 LYON 03 FRANCE CTR LEON BERARD,LAB CRYOBIOL F-69373 LYON FRANCE HOP JEAN BERNARD,SERV HEMATOL POITIERS FRANCE INST JULES BORDET,SERV HEMATOL B-1000 BRUSSELS BELGIUM HOSPICES CIVILS LYON,LAB INFORMAT MED LYON FRANCE
Titolo Testata:
British Journal of Haematology
fascicolo: 3, volume: 99, anno: 1997,
pagine: 678 - 684
SICI:
0007-1048(1997)99:3<678:GFGIAT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MYELOGENOUS LEUKEMIA; BONE-MARROW TRANSPLANTATION; HIGH-DOSE CHEMOTHERAPY; PROGENITOR CELLS; IN-VITRO; G-CSF; CHRONIC PHASE; HEMATOPOIETIC PROGENITORS; MONONUCLEAR-CELLS; T-LYMPHOCYTES;
Keywords:
CHRONIC MYELOID LEUKEMIA; THERAPY; AUTOGRAFT; FILGRASTIM; INTERFERON-ALPHA;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
E. Archimbaud et al., "GRANULOCYTE-COLONY-STIMULATING FACTOR GIVEN IN ADDITION TO INTERFERON-ALPHA TO MOBILIZE PERIPHERAL-BLOOD STEM-CELLS FOR AUTOLOGOUS TRANSPLANTATION IN CHRONIC MYELOID-LEUKEMIA", British Journal of Haematology, 99(3), 1997, pp. 678-684

Abstract

In order to potentially mobilize and harvest the Ph- cells observed in most patients with chronic myeloid leukaemia (CML) during interferon-alpha (IF-alpha) therapy, G-CSF (filgrastim), 5 mu g/kg/d, was administered subcutaneously together with IF-alpha to 30 CML patients in haematological remission but with various degrees of cytogenetic remission, after IF-alpha therapy. Peripheral blood stem cells (PBSC) were harvested using standard aphereses from day 5 of G-CSF. Patients underwent one to four (median three) aphereses. Median total yields/kg were 7.6 (range 3.8-25) x 10(8) MNC, 3.4 (0-140) x 10(6) CD34(+) cells, and 17 (1.1-107) x 10(4) CFU-GM, No patient had a significant increase in the percentage of Ph+ cells in the bone marrow under G-CSF therapy The percentage of Ph+ cells in apheresis products tended to decrease between the first and the last apheresis (P=0.05). 14 patients who were notresponsive to IF-alpha were transplanted after conditioning with busulphan 16 mg/kg and melphalan 140 mg/m(2). Median time to neutrophils >0.5 x 10(9)/l was 20 d (16-114 d) and to platelets >50 x 10(9)/l 18 d(12-149 d), Nine patients had a major cytogenetic response post graft, which correlated with the amount of Ph+ cells reinfused with the graft (P = 0.02). We conclude that this procedure is feasible, allowing the harvest of enough PBSC, some of them Ph- in patients who responded to IF-alpha, to allow autologous transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 21:13:14