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Titolo:
NEUROPROTECTIVE EFFECT OF DAPSONE AGAINST QUINOLINATE-INDUCED AND KAINATE-INDUCED STRIATAL NEUROTOXICITIES IN RATS
Autore:
SANTAMARIA A; ORDAZMORENO J; RUBIOOSORNIO M; SOLISHERNANDEZ F; RIOS C;
Indirizzi:
NATL INST NEUROL & NEUROSURG MANUEL VELASCO SUARE,DEPT NEUROCHEM,INSURGENTES SUR 3877 MEXICO CITY 14269 DF MEXICO NATL INST NEUROL & NEUROSURG MANUEL VELASCO SUARE,DEPT NEUROCHEM MEXICO CITY 14269 DF MEXICO
Titolo Testata:
Pharmacology & toxicology
fascicolo: 6, volume: 81, anno: 1997,
pagine: 271 - 275
SICI:
0901-9928(1997)81:6<271:NEODAQ>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED IMMUNODEFICIENCY SYNDROME; AMYGDALA-KINDLED SEIZURES; KAINIC ACID; HUNTINGTONS-DISEASE; EXCITOTOXIC PROPERTIES; PHYSIOLOGICAL FLUIDS; CEREBROSPINAL-FLUID; KYNURENIC ACID; AMINO-ACIDS; LESIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
A. Santamaria et al., "NEUROPROTECTIVE EFFECT OF DAPSONE AGAINST QUINOLINATE-INDUCED AND KAINATE-INDUCED STRIATAL NEUROTOXICITIES IN RATS", Pharmacology & toxicology, 81(6), 1997, pp. 271-275

Abstract

We tested the ability of dapsone, a well-known antibiotic and antiinflammatory drug, to attenuate both the quinolinic acid (an NMDA agonistof glutamate receptors)- and kainic acid (a non-NMDA agonist of glutamate receptors)-induced in vivo neurotoxicities in rats. Circling behaviour and striatal gamma-aminobutyric acid (GABA) depletion were considered as behavioural and neurochemical end-points of brain toxicity. Rotation behaviour, evaluated six days after the intrastriatal injection of quinolinic acid (130+/-19 ipsilateral turns/hr), was attenuated by doses of 12.5 mg/kg and 25 mg/kg of dapsone (50+/-9 and 63+/-9 turns/hr, respectively). Striatal GABA levels (237.3+/-15.1 mu g/g in control rats), found depleted at day 7 after quinolinic add (98.3+/-8.6 mu g/g), were also protected by dapsone at doses of 12.5 and 25 mg/kg (167.7+/-19.5 and 236.4+/-46.6 mu g/g, respectively). No protective effects were observed on quinolinic acid-induced neurotoxicity, as evaluated by both parameters, at lower doses of dapsone (6.25 and 9.375 mg/kg). The action of dapsone, at the dose of 12.5 mg/kg, was also measured on kainic acid-induced depletion of the striatal GABA levels. Animals treated with dapsone + kainic acid (182.8 +/- 27.1 mu g/g) showed significant attenuation of GABA depletion, as compared to rats treated with kainic acid alone (122.2 +/- 19.9 mu g/g). These findings provide evidences to suggest that dapsone is acting as a neuroprotective agent against excitotoxicity induced by glutamate receptor agonists.

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Documento generato il 03/04/20 alle ore 12:15:42