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Titolo:
EFFECT OF JAPANESE ANGELICA ROOT EXTRACT ON PENTOBARBITAL-INDUCED SLEEP IN GROUP-HOUSED AND SOCIALLY ISOLATED MICE - EVIDENCE FOR THE CENTRAL ACTION
Autore:
MATSUMOTO K; KOHNO S; TEZUKA Y; KADOTA S; WATANABE H;
Indirizzi:
TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU,DEPT PHARMACOL,2630 SUGITANI TOYAMA 93001 JAPAN TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU,DEPT NAT PROD CHEM TOYAMA 93001 JAPAN
Titolo Testata:
Japanese Journal of Pharmacology
fascicolo: 4, volume: 73, anno: 1997,
pagine: 353 - 356
SICI:
0021-5198(1997)73:4<353:EOJARE>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS COERULEUS; SYSTEMS; AROUSAL; STRESS; DRUGS; RATS;
Keywords:
ANGELICAE RADIX; SOCIAL ISOLATION STRESS; PENTOBARBITAL SLEEP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
K. Matsumoto et al., "EFFECT OF JAPANESE ANGELICA ROOT EXTRACT ON PENTOBARBITAL-INDUCED SLEEP IN GROUP-HOUSED AND SOCIALLY ISOLATED MICE - EVIDENCE FOR THE CENTRAL ACTION", Japanese Journal of Pharmacology, 73(4), 1997, pp. 353-356

Abstract

We investigated the effect of the aqueous extract of Japanese angelica root (JAR) on pentobarbital (PB) sleep in group-housed and socially isolated mice. The JAR extract (1.25-2.5 g/kg, p.o.) dose-dependently reversed the decrease in PB sleep caused by isolation stress without affecting PB sleep in group-housed mice. The JAR extract (2.5 g/kg, p.o.) also antagonized the decrease in PB sleep caused by the az-adrenoceptor antagonists yohimbine and idazoxan (1 mg/kg, i.p.) and the alpha(1)-adrenoceptor agonist methoxamine (200 nmol, i.c.v.) in group-housedmice. These results suggest that the JAR extract reverses changes in the arousal level caused by isolation stress and the activation of central noradrenergic systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 03:58:45