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Titolo:
PULSED HIGH-DOSE DEXAMETHASONE THERAPY IN CHILDREN WITH CHRONIC IDIOPATHIC THROMBOCYTOPENIC PURPURA
Autore:
CHEN JS; WU JM; CHEN YJ; YEH TF;
Indirizzi:
NATL CHENG KUNG UNIV HOSP,DEPT PEDIAT,138 SHENG LI RD TAINAN 704 TAIWAN
Titolo Testata:
Journal of pediatric hematology/oncology
fascicolo: 6, volume: 19, anno: 1997,
pagine: 526 - 529
SICI:
1077-4114(1997)19:6<526:PHDTIC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Keywords:
CHRONIC IDIOPATHIC THROMBOCYTOPENIA PURPURA; DEXAMETHASONE; PULSED THERAPY;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Chen et al., "PULSED HIGH-DOSE DEXAMETHASONE THERAPY IN CHILDREN WITH CHRONIC IDIOPATHIC THROMBOCYTOPENIC PURPURA", Journal of pediatric hematology/oncology, 19(6), 1997, pp. 526-529

Abstract

Purpose: The effectiveness of pulsed high-dose oral dexamethasone therapy in children with refractory chronic idiopathic thrombocytopenic purpura (ITP) is evaluated. Patients and Methods: Seven children (5 to 16 years old) who were refractory to 2 to 5 conventional standard therapies were included in the study. Dexamethasone was administered orally at a dosage of 40 mg/m(2) per day (maximum 40 mg/day) for 4 consecutive days as a cycle. The cycle was repeated once a month for 6 months. Results: One month after the first cycle, partial responses of platelet counts (greater than or equal to 50x10(9)/L and <150x10(9)/L) were observed in three patients (43%). At the end of the sixth cycle, two patients (29%) had complete responses (>150x10(9)/L) and one had a partial response. However, only one patient (14%) remained partially responsive 1 year after completion of therapy.Conclusions: In contrast to what was observed in adults, this preliminary study suggests that pulsed high-dose oral dexamethasone therapy was not uniformly effective in children with chronic ITP.

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Documento generato il 12/07/20 alle ore 12:30:38