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Titolo:
SUBTYPES Y1 AND Y2 OF THE NEUROPEPTIDE-Y RECEPTOR ARE RESPECTIVELY EXPRESSED IN PRO-OPIOMELANOCORTIN-CONTAINING AND NEUROPEPTIDE-Y-CONTAINING NEURONS OF THE RAT HYPOTHALAMIC ARCUATE NUCLEUS
Autore:
BROBERGER C; LANDRY M; WONG H; WALSH JN; HOKFELT T;
Indirizzi:
KAROLINSKA INST,DEPT NEUROSCI S-17177 STOCKHOLM SWEDEN CURE,GASTROENTER BIOL CTR LOS ANGELES CA 00000
Titolo Testata:
Neuroendocrinology
fascicolo: 6, volume: 66, anno: 1997,
pagine: 393 - 408
SICI:
0028-3835(1997)66:6<393:SYAYOT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA; PARAVENTRICULAR NUCLEUS; PANCREATIC-POLYPEPTIDE; PEPTIDE-YY; FUNCTIONAL EXPRESSION; INSITU HYBRIDIZATION; FEEDING-BEHAVIOR; FOOD-DEPRIVATION; GENE-EXPRESSION; BRAIN PEPTIDE;
Keywords:
PROOPIOMELANOCORTIN; ARCUATE NUCLEUS; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTORS; FEEDING; VENTROMEDIAL NUCLEUS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
C. Broberger et al., "SUBTYPES Y1 AND Y2 OF THE NEUROPEPTIDE-Y RECEPTOR ARE RESPECTIVELY EXPRESSED IN PRO-OPIOMELANOCORTIN-CONTAINING AND NEUROPEPTIDE-Y-CONTAINING NEURONS OF THE RAT HYPOTHALAMIC ARCUATE NUCLEUS", Neuroendocrinology, 66(6), 1997, pp. 393-408

Abstract

The arcuate nucleus of the hypothalamus houses a number of neurochemically different cell populations. Among these, a dense cluster of small neuropeptide-Y (NPY)-expressing neurons is located in its ventromedial subdivision and a pro-opiomelanocortin (POMC)-expressing neuron population in its ventrolateral part. Furthermore, both neuropeptide Y Y1and Y2 receptors (Y1-Rs and Y2-Rs) are expressed in the arcuate nucleus. Here we analyse the co-expression of NPY and POMC/adrenocorticotropic hormone with the Y1-R and Y2-R in arcuate neurons using immunohistochemistry and in situ hybridization. Many, but not all, POMC neurons expressed Y1-R mRNA and protein. Conversely, several Y1-R-positive, POMC-negative neurons were found. NPY-positive nerve terminals were found in close apposition to Y1-R-like immunoreactivity localized close tothe dendritic and somatic cell membranes. Y2-R mRNA was found in almost all NPY mRNA-expressing neurons, but also in a group of NPY mRNA-negative cells. These results show that the POMC neurons are targets forNPY, which is presumably present in, and released from, fibres originating in the ventromedial arcuate nucleus and which may play a role inNPY-induced feeding. Release of NPY, and possible coexisting messengers, may be controlled by presynaptic Y2-R expressed in NPY neurons. Taken together, the findings support the division of Y1-Rs and Y2-Rs into post- and presynaptic receptors, respectively.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 18:39:46