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Titolo:
THE EFFECT OF 7-NITRO INDAZOLE ON PENTOBARBITAL-INDUCED SLEEP IN MICE
Autore:
ERDEN BF; ULAK G; YILDIRAN G; GACAR N;
Indirizzi:
KOCAELI UNIV,FAC MED,DEPT PHARMACOL TR-41900 DERINCE KOSCAELI TURKEY
Titolo Testata:
Pharmacological research
fascicolo: 4, volume: 36, anno: 1997,
pagine: 265 - 267
SICI:
1043-6618(1997)36:4<265:TEO7IO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; L-ARGININE; INHIBITION;
Keywords:
NITRIC OXIDE; 7-NITRO INDAZOLE; L-ARGININE; PENTOBARBITAL SLEEP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
B.F. Erden et al., "THE EFFECT OF 7-NITRO INDAZOLE ON PENTOBARBITAL-INDUCED SLEEP IN MICE", Pharmacological research, 36(4), 1997, pp. 265-267

Abstract

The sleep-wakefulness continuity is sensitive to a wide range of agents with pharmacological activity. There is some strong evidence about the role of nitric oxide (NO) as an intercellular messenger in the central physiological mechanisms. The effects of 7-nitro indazole (7-NI 15, 30, 60 mg kg(-1); intraperitoneal, i.p.), a selective inhibitor of neuronal nitric oxide synthase (NOS) and L-arginine (500, 1000 mg kg(-1), i.p.), a NO precursor, on pentobarbital (35 mg kg(-1), i.p.) sleepwere examined in mice. Loss of the righting reflex was used to determine the start of sleep. Sleep latency and sleeping time were evaluatedin each experiment. 7-Nitro indazole (7-NI 30 mg kg(-1); i.p.), had no apparent effect on sleep latency but significantly increased sleeping time (P < 0.02) on pentobarbital sleep in mice. L-Arginine had no effect on both parameters. These findings suggest that NO might be an important modulator of sleep regulation and implicate that inhibition ofrelease and/or synthesis of NO might lead to changes in the maintenance of sleep. (C) 1997 The Italian Pharmacological Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:44:07