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Titolo:
CHEMICAL OXIDATION AND DNA-DAMAGE CATALYZED BY INORGANIC SUNSCREEN INGREDIENTS
Autore:
DUNFORD R; SALINARO A; CAI LZ; SERPONE N; HORIKOSHI S; HIDAKA H; KNOWLAND J;
Indirizzi:
UNIV OXFORD,DEPT BIOCHEM,S PARKS RD OXFORD OX1 3QU ENGLAND UNIV OXFORD,DEPT BIOCHEM OXFORD OX1 3QU ENGLAND CONCORDIA UNIV,DEPT CHEM & BIOCHEM MONTREAL PQ H3G 1M8 CANADA MEISEI UNIV,DEPT CHEM HINO TOKYO 191 JAPAN
Titolo Testata:
FEBS letters
fascicolo: 1-2, volume: 418, anno: 1997,
pagine: 87 - 90
SICI:
0014-5793(1997)418:1-2<87:COADCB>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
TITANIUM; PHOTOCATALYSIS; CELLS;
Keywords:
SUNSCREEN; TITANIUM DIOXIDE; ZINC OXIDE; DNA DAMAGE; HYDROXYL RADICAL;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
R. Dunford et al., "CHEMICAL OXIDATION AND DNA-DAMAGE CATALYZED BY INORGANIC SUNSCREEN INGREDIENTS", FEBS letters, 418(1-2), 1997, pp. 87-90

Abstract

Titanium dioxide (TiO2) has been noted (US Federal Register, 43FR38206, 25 August 1978) to be a safe physical sunscreen because it reflectsand scatters UVB and UVA in sunlight. However, TiO2 absorbs about 70%of incident UV, and in aqueous environments this leads to the generation of hydroxyl radicals which can initiate oxidations, Using chemicalmethods, we show that all sunscreen TiO2 samples tested catalyse the photo-oxidation of a representative organic substrate (phenol), We also show that sunlight-illuminated TiO2 catalyses DNA damage both in vitro and in human cells, These results may be relevant to the overall effects of sunscreens. (C) 1997 Federation of European Biochemical Societies.

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Documento generato il 11/07/20 alle ore 07:47:22