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Titolo:
2 ANGSTROM X-RAY STRUCTURE OF ADAMALYSIN-II COMPLEXED WITH A PEPTIDE PHOSPHONATE INHIBITOR ADOPTING A RETRO-BINDING MODE
Autore:
CIRILLI M; GALLINA C; GAVUZZO E; GIORDANO C; GOMISRUTH FX; GORINI B; KRESS LF; MAZZA F; PARADISI MP; POCHETTI G; POLITI V;
Indirizzi:
CNR,IST STRUTTURIST CHIM,CP 10 I-00016 MONTEROTONDO ROME ITALY CNR,IST STRUTTURIST CHIM I-00016 MONTEROTONDO ROME ITALY UNIV ROMA LA SAPIENZA,CNR,CTR CHIM FARMACO I-00185 ROME ITALY CSIC,CTR INVEST & DESENVOLUPOMENT,DEPT MOL & CELLULAR BIOL ES-08034 BARCELONA SPAIN ROSWELL PK CANC INST,DEPT MOL & CELLULAR BIOL BUFFALO NY 14263 POLIFARMA RES CTR I-00155 ROME ITALY
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 418, anno: 1997,
pagine: 319 - 322
SICI:
0014-5793(1997)418:3<319:2AXSOA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSITION-STATE ANALOGS; SNAKE-VENOM; MATRIX METALLOPROTEINASES; CRYSTAL-STRUCTURE; ZINC-PEPTIDASES; PROTEIN; THERMOLYSIN; COLLAGENASE; FAMILY; METALLOENDOPEPTIDASES;
Keywords:
X-RAY CRYSTAL STRUCTURE; ZINC-ENDOPEPTIDASE; SNAKE VENOM PROTEINASE; PHOSPHONATE INHIBITOR; TUMOR NECROSIS FACTOR-ALPHA-CONVERTING ENZYME;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
M. Cirilli et al., "2 ANGSTROM X-RAY STRUCTURE OF ADAMALYSIN-II COMPLEXED WITH A PEPTIDE PHOSPHONATE INHIBITOR ADOPTING A RETRO-BINDING MODE", FEBS letters, 418(3), 1997, pp. 319-322

Abstract

The search of reprolysin inhibitors offers the possibility of intervention against both matrixins and ADAMs. Here we report the crystal structure of the complex between adamalysin II, a member of the reprolysin family, and a phosphonate inhibitor modeled on an endogenous venom tripeptide, The inhibitor occupies the primed region of the cleavage site adopting a retro-binding mode, The phosphonate group ligates the zinc ion in an asymmetric bidentate mode and the adjacent Trp indole system partly fills the primary specificity subsite S-1'. An adamalysin-based model of tumor necrosis factor-alpha-converting enzyme (TACE) reveals a smaller S-1' pocket for this enzyme. (C) 1997 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 22:52:30