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Titolo:
DOPAMINE-RECEPTOR TRANSCRIPT EXPRESSION IN STRIATUM AND PREFRONTAL AND OCCIPITAL CORTEX - FOCAL ABNORMALITIES IN ORBITOFRONTAL CORTEX IN SCHIZOPHRENIA
Autore:
MEADORWOODRUFF JH; HAROUTUNIAN V; POWCHIK P; DAVIDSON M; DAVIS KL; WATSON SJ;
Indirizzi:
UNIV MICHIGAN,DEPT PSYCHIAT,MENTAL HLTH RES INST,205 ZINA PITCHER PL ANN ARBOR MI 48109 MT SINAI SCH MED,DEPT PSYCHIAT NEW YORK NY 00000 CHAIM SHEBA MED CTR IL-52621 TEL HASHOMER ISRAEL
Titolo Testata:
Archives of general psychiatry
fascicolo: 12, volume: 54, anno: 1997,
pagine: 1089 - 1095
SICI:
0003-990X(1997)54:12<1089:DTEISA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHYSIOLOGICAL DYSFUNCTION; NEURONAL-ACTIVITY; GENE-EXPRESSION; MESSENGER-RNA; D-4 RECEPTORS; D4 RECEPTORS; HUMAN-BRAIN; BINDING; MONKEY; CLONING;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
J.H. Meadorwoodruff et al., "DOPAMINE-RECEPTOR TRANSCRIPT EXPRESSION IN STRIATUM AND PREFRONTAL AND OCCIPITAL CORTEX - FOCAL ABNORMALITIES IN ORBITOFRONTAL CORTEX IN SCHIZOPHRENIA", Archives of general psychiatry, 54(12), 1997, pp. 1089-1095

Abstract

Background: The identification of novel subtypes of the dopamine receptors has renewed interest in the involvement of dopaminergic mechanisms in schizophrenia. We determined the expression of transcripts encoding the dopamine receptors in the brains of schizophrenic patients. Methods: The levels of the messenger RNA molecules encoding the 5 dopamine receptors were quantified in postmortem brain samples from 16 schizophrenic patients and 9 control subjects. Samples from multiple regions of the prefrontal cortex, primary visual cortex, and striatum were subjected to in situ hybridization followed by quantitative image analysis. Results: Expression of dopamine receptor transcripts did not differ between schizophrenic patients and controls in striatum or visual cortex. Dramatic decreases of dopamine receptor transcripts were found in the prefrontal cortex, but these changes were restricted to the D-3and D-4 receptors, and localized to Brodmann area 11 (orbitofrontal cortex). Conclusions: Cortical dopaminergic neurotransmission may be disrupted in schizophrenia at the level of receptor expression. There appears to be a focal abnormality of D-3 and D-4 messenger RNA expression in the prefrontal cortex, with down-regulation of both, consistent with prefrontal cortical hypodopaminergia in schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:58:46