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Titolo:
URINARY ASSAYS FOR DESMOSINE AND HYDROXYLYSYLPYRIDINOLINE IN THE DETECTION OF CIRRHOSIS
Autore:
AFDHAL NH; KEAVENY AP; COHEN SB; NUNES DP; MALDONADO N; OBRIEN M; STONE PJ;
Indirizzi:
BOSTON MED CTR,GASTROENTEROL SECT,EVANS DEPT MED,EVANS 201,1 BOSTON MED CTR PLAZA BOSTON MA 02118 BOSTON MED CTR,THORNDIKE MEM LABS,DEPT PATHOL BOSTON MA 02118 BOSTON MED CTR,THORNDIKE MEM LABS,DEPT BIOCHEM BOSTON MA 02118 BOSTON UNIV,SCH MED BOSTON MA 02215
Titolo Testata:
Journal of hepatology
fascicolo: 6, volume: 27, anno: 1997,
pagine: 993 - 1002
SICI:
0168-8278(1997)27:6<993:UAFDAH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLLAGEN DEGRADATION PRODUCTS; CHRONIC VIRAL-HEPATITIS; PYRIDINIUM CROSS-LINKS; CHRONIC LIVER-DISEASE; CENTRAL TRIPLE-HELIX; III PROCOLLAGEN; ALPHA-INTERFERON; BONE-RESORPTION; IV COLLAGEN; FIBROSIS;
Keywords:
CIRRHOSIS; DESMOSINE; FIBROSIS; HEPATITIS C; HYDROXYLYSYLPYRIDINOLINE; ISODESMOSINE; PROCOLLAGEN PEPTIDE III;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
N.H. Afdhal et al., "URINARY ASSAYS FOR DESMOSINE AND HYDROXYLYSYLPYRIDINOLINE IN THE DETECTION OF CIRRHOSIS", Journal of hepatology, 27(6), 1997, pp. 993-1002

Abstract

Background/Aims: Non-invasive markers of liver fibrosis have great potential for both the diagnosis and therapy of liver disease and cirrhosis, The aim of this study was to evaluate the potential of urinary amino acids desmosine (DES) and isodesmosine (IDES) derived from the breakdown of elastin and hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) derived from fibrillar collagen in diagnosing chronic liver disease, Methods: We studied 48 patients with chronic liver disease whohad varying degrees of liver fibrosis, graded 0-6 using a modified Knodell score, and 20 control subjects without liver disease, Urinary DES (mu g/g creatinine) and HP (nmol/mmol creatinine) were measured by an isotope dilution, high performance liquid chromatography method, Forliver disease patients, aminoterminal propeptide of type III procollagen (PIIINP) and alanine aminotransferase were determined, The urine and serum markers were correlated to degree of fibrosis and inflammation on liver biopsies, Differences between groups were analyzed by ANOVAand multiple linear regression was applied determine independence of variables, Sensitivity, specificity and receiver operating curves werederived for each marker. Results: In the 17 patients with liver fibrosis score of 5-6, mean urinary DES, IDES, KP and LP were all significantly greater than in the control group (p<0.05), Urinary DES and IDES correlated best with fibrosis score, r=0.61 for both markers. The correlation coefficient between serum PIIINP and fibrosis score was 0.47, Urinary DES and HP each had an overall diagnostic accuracy of 77% for fibrosis. Combining markers improved accuracy to over 80%. No correlation was seen between the urinary markers and inflammation scores. Conclusions: Urinary DES and HP are potentially useful clinical markers for liver fibrosis, especially when used in combination or in association with PIIINP.

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Documento generato il 15/07/20 alle ore 14:29:55