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Titolo:
IN-UTERO TRANSPLANTATION OF FETAL HEMATOPOIETIC-CELLS IN THE MOUSE - THE EFFECT OF DONOR AND RECIPIENT GESTATIONAL MATURITY
Autore:
TAKEYAMA Y; UEHARA S; OKAMURA K; YAJIMA A;
Indirizzi:
TOHOKU UNIV,DEPT OBSTET & GYNECOL,SCH MED SENDAI MIYAGI 98077 JAPAN
Titolo Testata:
Tohoku Journal of Experimental Medicine
fascicolo: 2, volume: 183, anno: 1997,
pagine: 113 - 122
SICI:
0040-8727(1997)183:2<113:ITOFHI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEM-CELLS; INUTERO TRANSPLANTATION; SHEEP; ENGRAFTMENT; CHIMERISM;
Keywords:
FETAL LIVER HEMATOPOIETIC CELL; IN-UTERO TRANSPLANTATION; INTRAPERITONEAL TRANSPLANTATION; COLONY ASSAY; CELL DIFFERENTIATION;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
Y. Takeyama et al., "IN-UTERO TRANSPLANTATION OF FETAL HEMATOPOIETIC-CELLS IN THE MOUSE - THE EFFECT OF DONOR AND RECIPIENT GESTATIONAL MATURITY", Tohoku Journal of Experimental Medicine, 183(2), 1997, pp. 113-122

Abstract

To investigate the possibility of engrafting fetal liver hematopoietic cells by in utero intraperitoneal transplantation, we transplanted donor cells obtained from mouse fetuses at 13, 15 and 17 days of gestation to mouse fetuses at 15, 16 and 17 days of gestation. Engraftment was assessed by Sry gene amplification of DNA extracted from peripheralblood samples of transplanted mice six weeks after birth. In comparison, me performed an in vitro colony-assay of fetal liver cells at 13, 15, and 17 days of gestation. The incidence of engraftment was significantly higher in cells of 15 days of gestation then in cells of 13 or 17 days of gestation, whereas the colony forming activity decreased gradually from 13 to 15 days of gestation. From these results, we suggest that the 15 day liver contains hematopoietic progenitors which have the specific characteristics required for engraftment by intraperitoneal transplantation. (C) 1997 Tohoku University Medical Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:27:30