Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ANTIINFLAMMATORY ACTION OF DAPSONE - INHIBITION OF NEUTROPHIL ADHERENCE IS ASSOCIATED WITH INHIBITION OF CHEMOATTRACTANT-INDUCED SIGNAL-TRANSDUCTION
Autore:
DEBOL SM; HERRON MJ; NELSON RD;
Indirizzi:
UNIV MINNESOTA,SCH MED,DEPT MICROBIOL,BOX 98 UMHC MINNEAPOLIS MN 55455 UNIV MINNESOTA,SCH MED,DEPT MICROBIOL MINNEAPOLIS MN 55455 UNIV MINNESOTA,SCH MED,DEPT DERMATOL MINNEAPOLIS MN 55455
Titolo Testata:
Journal of leukocyte biology
fascicolo: 6, volume: 62, anno: 1997,
pagine: 827 - 836
SICI:
0741-5400(1997)62:6<827:AAOD-I>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; NUCLEOTIDE REGULATORY PROTEIN; FLUORIDE-TREATED NEUTROPHILS; ISLET-ACTIVATING PROTEIN; POLYMORPHONUCLEAR LEUKOCYTES; PERTUSSIS TOXIN; DERMATITIS-HERPETIFORMIS; CHEMOTACTIC FACTORS; ADP-RIBOSYLATION; MEMBRANE-PROTEIN;
Keywords:
DERMATITIS HERPETIFORMIS; BETA(2) INTEGRIN; G-PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Debol et al., "ANTIINFLAMMATORY ACTION OF DAPSONE - INHIBITION OF NEUTROPHIL ADHERENCE IS ASSOCIATED WITH INHIBITION OF CHEMOATTRACTANT-INDUCED SIGNAL-TRANSDUCTION", Journal of leukocyte biology, 62(6), 1997, pp. 827-836

Abstract

Dapsone has clinical utility as an antiinflammatory agent but the mechanism of this action remains unknown. We have previously reported that dapsone inhibits beta(2) integrin (CD11b/CD18)-mediated adherence ofhuman neutrophils in vitro and now describe studies designed to discover how dapsone-mediated inhibition of this neutrophil function occurs, Results indicate that dapsone interferes with the activation or function of the G-protein (G(i) type) that initiates the signal transduction cascade common to chemotactic stimuli, They also show that dapsone-mediated suppression of this pathway inhibits the generation of secondmessengers essential to tile activation of beta(2) integrin molecules, as well as respiratory and secretory functions of neutrophils exposed to chemoattractants. We propose that the inhibition of chemoattractant-induced signal transduction by dapsone suppresses neutrophil recruitment and local production of toxic respiratory and secretory productsin the affected shin of dermatitis herpetiformis and other neutrophilic dermatoses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 04:19:39