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Titolo:
METHODS FOR DIAGNOSING TUBERCULOSIS AMONG INPATIENTS IN EASTERN AFRICA WHOSE SPUTUM SMEARS ARE NEGATIVE
Autore:
SAMB B; HENZEL D; DALEY CL; MUGUSI F; NIYONGABO T; MLIKACABANNE N; KAMANFU G; AUBRY P; MBAGA I; LAROUZE B; MURRAY JF;
Indirizzi:
GRP HOSP BICHAT CLAUDE BERNARD,INSERM U13,IMEA,46 RUE HENRI HUCHARD F-75018 PARIS FRANCE IMEA,INSERM U13 PARIS FRANCE UNIV CALIF SAN FRANCISCO,SAN FRANCISCO GEN HOSP,MED CTR SAN FRANCISCOCA 94143 MUHIMBILI MED CTR DAR ES SALAAM TANZANIA CHU KAMENGE BUJUMBURA BURUNDI HOP IA ROBERT PICQUE BORDEAUX FRANCE
Titolo Testata:
The international journal of tuberculosis and lung disease
fascicolo: 1, volume: 1, anno: 1997,
pagine: 25 - 30
SICI:
1027-3719(1997)1:1<25:MFDTAI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; DAR-ES-SALAAM; RADIOGRAPHIC ABNORMALITIES; PULMONARY COMPLICATIONS; INFECTION; TANZANIA; RISK;
Keywords:
TUBERCULOSIS; SMEAR-NEGATIVE; DIAGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
B. Samb et al., "METHODS FOR DIAGNOSING TUBERCULOSIS AMONG INPATIENTS IN EASTERN AFRICA WHOSE SPUTUM SMEARS ARE NEGATIVE", The international journal of tuberculosis and lung disease, 1(1), 1997, pp. 25-30

Abstract

SETTING: Two University hospitals in Eastern African capital cities where large prospective Studies had been carried out on hospitalized patients-to determine the cause of their respiratory diseases. OBJECTIVE: To identify features that differentiated between tuberculosis (TB) and non-tuberculous respiratory disease (non-TB) in hospitalized patients from Bujumbura, Burundi (n = 111) and Dar es Salaam, Tanzania (n = 71) whose sputum smears were negative on microscopic examination for acid-fast bacilli (AFB).DESIGN: Review of clinical findings, radiologicabnormalities, and laboratory test results from 182 patients, first by univariate and then by multivariate (stepwise logistic regression) analysis to assess the contribution of each factor to the final diagnosis. RESULTS: Of the 182 patients with two or more negative AFB smears,41 had TB and 141 had non-TB. Stepwise regression analysis revealed four easily ascertained symptoms were associated with TB: 1) cough >21 days; 2) chest pain >15 days; 3) absence of expectoration; and 4) absence of shortness of breath. Any two of the four diagnosed TB with 85% sensitivity and 67% specificity; any three of the four with 49% sensitivity and 86% specificity. Multivariate analysis showed that adding lymphadenopathy and hematocrit <30% improved discrimination. CONCLUSION:This methodological approach provides a means for diagnosing TB amongall AFB smear-negative hospitalized patients. In this setting, simpleclinical symptoms alone are helpful. Similar studies are needed to develop a system for out-patient TB suspects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:01:50