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Titolo:
NEUROCHEMICAL MECHANISMS OF NITROGLYCERIN-INDUCED NEURONAL ACTIVATIONIN RAT-BRAIN - A PHARMACOLOGICAL INVESTIGATION
Autore:
TASSORELLI C; JOSEPH SA; NAPPI G;
Indirizzi:
UNIV PAVIA,NEUROL INST C MONDINO,VIA PALESTRO 3 I-27100 PAVIA ITALY UNIV ROCHESTER,STRONG MEM HOSP,MED CTR,DIV NEUROL SURG ROCHESTER NY 14642
Titolo Testata:
Neuropharmacology
fascicolo: 10, volume: 36, anno: 1997,
pagine: 1417 - 1424
SICI:
0028-3908(1997)36:10<1417:NMONNA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXHIBITS ANTINOCICEPTIVE ACTIVITY; FOS-LIKE IMMUNOREACTIVITY; NITRIC-OXIDE SYNTHASE; TOLERANCE DEVELOPMENT; GLYCERYL TRINITRATE; 7-NITRO INDAZOLE; BLOOD-PRESSURE; AXONAL INPUT; EXPRESSION; HYPOTENSION;
Keywords:
CAPSAICIN; EPHEDRINE; INDOMETHACIN; NITRIC OXIDE; NOS INHIBITORS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
C. Tassorelli et al., "NEUROCHEMICAL MECHANISMS OF NITROGLYCERIN-INDUCED NEURONAL ACTIVATIONIN RAT-BRAIN - A PHARMACOLOGICAL INVESTIGATION", Neuropharmacology, 36(10), 1997, pp. 1417-1424

Abstract

Nitroglycerin is a nitric oxide donor which induces sustained expression of Fos protein, a marker of neuronal activation, in specific neuronal groups in the central nervous system. The mechanisms which underlie nitroglycerin-induced neuronal activation are elusive at this time, although a precise role has been suggested for the pool of neurons containing nitric oxide synthase as well as for catecholaminergic and peptidergic pathways. The aim of this study was to provide further details on the central effect of nitroglycerin by means of a pharmacologicalmanipulation of nitroglycerin-induced neuronal activation with inhibitors of the nitric oxide synthase, modulators of the sympathetic driveand mediators of pain perception. Adult male Sprague-Dawley rats received L-N(G)nitro-arginine methyl ester, 7-nitro-indazole, ephedrine sulfate, indomethacin, capsaicin or vehicle before the subcutaneous injection of nitroglycerin (10 mg/kg b.w.). They were sacrificed 4hr afternitroglycerin administration and brain sections were processed for immunocytochemical visualization of Fos. All the pharmacological treatments administered before injecting nitroglycerin selectively influencedFos expression in the different brain nuclei. The data obtained suggest that nitroglycerin-induced neuronal activation is mediated by nociceptive and barosensitive mechanisms. Nitric oxide seems to represent the most important mediator of this phenomenon. The sympathetic system and prostaglandin synthesis are also likely to be involved. (C) 1997 Published by Elsevier Science Ltd.

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Documento generato il 04/07/20 alle ore 17:51:17