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Titolo:
XANTHINE-OXIDASE DECREASES PRODUCTION OF GUT WALL NITRIC-OXIDE
Autore:
TERADA LS; RADISAVLJEVIC Z; MAHR NN; JACOBSON ED;
Indirizzi:
UNIV COLORADO,HLTH SCI CTR,DEPT MED,SCH MED,BOX C-321,4200 E 9TH AVE DENVER CO 80262 UNIV COLORADO,HLTH SCI CTR,DEPT MED,SCH MED DENVER CO 80262
Titolo Testata:
Proceedings of the Society for Experimental Biology and Medicine
fascicolo: 3, volume: 216, anno: 1997,
pagine: 410 - 413
SICI:
0037-9727(1997)216:3<410:XDPOGW>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTESTINAL ISCHEMIA-REPERFUSION; SYSTEMIC ORGAN INJURY; ACID ASPIRATION; LUNG INJURY; PERMEABILITY; DYSFUNCTION;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
L.S. Terada et al., "XANTHINE-OXIDASE DECREASES PRODUCTION OF GUT WALL NITRIC-OXIDE", Proceedings of the Society for Experimental Biology and Medicine, 216(3), 1997, pp. 410-413

Abstract

Multiorgan failure is often the lethal outcome of intratracheal aspiration of acidic gastric juice, The pathogenesis of multiorgan failure may involve a systemic imbalance between pro-inflammatory and anti-inflammatory factors. in an anesthetized rat model, intratracheal Instillation of HCl elicited intestinal inflammation which was exaggerated byxanthine oxidase (XQ) and attenuated by nitric oxide (NO). We hypothesized that XO may mediate injury in part by suppression of NO formation, Therefore, we measured intestinal tissue concentrations of: the stable NO oxidative metabolites (NO2- and NO3-) following intratracheal (IT) instillation of NaCl or HCl alone off in combination with interventions aimed at increasing or decreasing XO activity, Compared with IT NaCl (control treatment) jejunal tissue NO2- and NO2- + NO3- concentrations were increased by allopurinol pretreatment, which inhibits XO, and were decreased by systemically administered XO, as well as by IT HCl. The decreased NO2- and NO2- + NO3- concentrations found following IT HCl were completely reversed by either allopurinol or by systemically administered L-arginine (the precursor of NO), We conclude that manipulation of the pro-inflammatory XO system has a reciprocal effect on the intestinal anti-inflammatory NO system in either the undamaged or the endobronchially acidified lung model.

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Documento generato il 21/09/20 alle ore 11:47:21