Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
AMYOTROPHIC-LATERAL-SCLEROSIS - LESSONS IN TRIAL DESIGN FROM RECENT TRIALS
Autore:
BORASIO GD;
Indirizzi:
UNIV MUNICH,KLINIKUM GROSSHADERN,DEPT NEUROL D-81366 MUNICH GERMANY
Titolo Testata:
Journal of the neurological sciences
, volume: 152, anno: 1997, supplemento:, 1
pagine: 23 - 28
SICI:
0022-510X(1997)152:<23:A-LITD>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOTOR-NEURON DISEASE; PLACEBO-CONTROLLED TRIAL; SICKNESS IMPACT PROFILE; CLINICAL-TRIAL; DOUBLE-BLIND; VENTILATION; RILUZOLE; OUTCOMES; RHCNTF; ALS;
Keywords:
AMYOTROPHIC LATERAL SCLEROSIS; TRIAL DESIGN; COMPARABILITY; DISEASE PROGRESSION; QUALITY OF LIFE;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
G.D. Borasio, "AMYOTROPHIC-LATERAL-SCLEROSIS - LESSONS IN TRIAL DESIGN FROM RECENT TRIALS", Journal of the neurological sciences, 152, 1997, pp. 23-28

Abstract

The recent history of clinical trials in ALS is marked by a great diversity in trial design. This has limited the comparability of the trial results, and has resulted in intense discussions about which parameters should or should not be evaluated when testing a new drug for ALS. This article discusses, without any claim to completeness, some aspects of trial design in relation to past, ongoing and future ALS trials,including: choice of endpoints, measurement of disease progression, assessment of quality of life, placebo-controlled trials, open-label trials, collaboration with the industry, and methods for investigating mechanisms of action of experimental drugs. (C) 1997 Elsevier Science B. V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 00:16:57