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Titolo:
MEASUREMENT OF INHIBIN AND ACTIVIN IN EARLY HUMAN-PREGNANCY - DEMONSTRATION OF FETOPLACENTAL ORIGIN AND ROLE IN PREDICTION OF EARLY-PREGNANCY OUTCOME
Autore:
LOCKWOOD GM; LEDGER WL; BARLOW DH; GROOME NP; MUTTUKRISHNA S;
Indirizzi:
JOHN RADCLIFFE HOSP,NUFFIELD DEPT OBSTET & GYNAECOL OXFORD OX3 9DU ENGLAND UNIV OXFORD,NUFFIELD DEPT OBSTET & GYNAECOL OXFORD OX3 9DU ENGLAND OXFORD BROOKES UNIV,SCH BIOL & MOL SCI OXFORD OX3 0BP ENGLAND
Titolo Testata:
Biology of reproduction
fascicolo: 6, volume: 57, anno: 1997,
pagine: 1490 - 1494
SICI:
0006-3363(1997)57:6<1490:MOIAAI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MENSTRUAL-CYCLE; 2-SITE ENZYME-IMMUNOASSAY; DIMERIC INHIBIN; SERUM CONCENTRATIONS; MATERNAL SERUM; DOWNS-SYNDROME; FORMS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
G.M. Lockwood et al., "MEASUREMENT OF INHIBIN AND ACTIVIN IN EARLY HUMAN-PREGNANCY - DEMONSTRATION OF FETOPLACENTAL ORIGIN AND ROLE IN PREDICTION OF EARLY-PREGNANCY OUTCOME", Biology of reproduction, 57(6), 1997, pp. 1490-1494

Abstract

To determine the source of the dimeric glycoproteins inhibin A (alpha-beta A) and activin A (beta A-beta A) in early pregnancy, we analyzedserial blood samples from women who became pregnant following in vitro fertilization (IVF) with fresh embryo transfer (ET; n = 52) and fromwomen who achieved pregnancy with frozen-thawed embryos (n = 8). Elevated serum levels of inhibin A were detected in ongoing pregnancies from 4 wk gestation (13 days following ET) and increased to an initial peak at 9-10 wk gestation. Significantly higher levels (p < 0.05) were found in the multiple pregnancies, and nonviable clinical pregnancies had very low levels of inhibin A. Total activin A was detectable 14 days after ET (positive pregnancy test), and higher levels were associated with multiple gestations while rapidly falling levels heralded embryonic demise. The fetoplacental unit is thus confirmed as the major source of these glycoproteins. Inhibin pro-alpha C which circulates in great excess as a functionally inactive monomer and as part of high molecular weight functional dimers, was detectable at levels above normallate-luteal values in singleton and multiple IVF arising from fresh ETs. With frozen-thawed embryo pregnancies, the levels of pro-alpha C-containing inhibins were extremely low, confirming that the corpus luteum of pregnancy is the major source of the alpha monomer. The initially low levels and very rapid decline in inhibin A in pregnancies with embryonic failure suggest a role for this glycoprotein as a monitor of early-pregnancy viability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 13:40:22