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Titolo:
INTERACTIONS OF ETHANOL WITH NICOTINE, DIZOCILPINE, CGP-40116, AND 1-(M-CHLOROPHENYL)-BIGUANIDE IN RATS
Autore:
BIENKOWSKI P; KOROS E; PIASECKI J; KOSTOWSKI W;
Indirizzi:
INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST,AL SOBIESKIEGO 1-9 PL-02957 WARSAW POLAND INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST PL-02957WARSAW POLAND MED ACAD WARSAW,DEPT EXPT & CLIN PHARMACOL PL-02927 WARSAW POLAND
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 58, anno: 1997,
pagine: 1159 - 1165
SICI:
0091-3057(1997)58:4<1159:IOEWND>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA RECEPTOR ANTAGONISTS; MONOAMINE-DEPLETED MICE; D-ASPARTATE ANTAGONISTS; GATED ION CHANNELS; NUCLEUS-ACCUMBENS; DOPAMINE RELEASE; ACETYLCHOLINE-RECEPTORS; LOCOMOTOR STIMULATION; 5-HT3 ANTAGONIST; MOTOR-ACTIVITY;
Keywords:
ETHANOL; NICOTINE; DIZOCILPINE; CGP 40116; 1-(M-CHLOROPHENYL)-BIGUANIDE; LOCOMOTION; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
P. Bienkowski et al., "INTERACTIONS OF ETHANOL WITH NICOTINE, DIZOCILPINE, CGP-40116, AND 1-(M-CHLOROPHENYL)-BIGUANIDE IN RATS", Pharmacology, biochemistry and behavior, 58(4), 1997, pp. 1159-1165

Abstract

The present study examined the effect of ethanol (0.25-1.0 g/kg, IF) alone and in combination with drugs affecting different Ligand-gated ion channels on a horizontal locomotor activity of male Wistar rats. None of the drugs given alone affected the locomotor activity. Similarly, combining ethanol either with nicotine (0.1 or 0.6 mg/kg, SC) or thecompetitive NMDA receptor antagonist, CGP 40116 (0.5 mg/kg, LP) did not result in any significant changes in ambulation. On the other hand,a significant hyperadditive interaction between ethanol (0.5 or 1.0 g/kg) and the uncompetitive NMDA receptor antagonist, dizocilpine (0.1 mg/kg, IP) was found. Thus, a combined administration of ethanol and dizocilpine produced a marked stimulation of the locomotor activity. Combining 1.0 g/kg ethanol with the 5-HT3 receptor agonist, 1-(m-chlorophenyl)-biguanide (5.0 mg/kg, IP) tended to produce locomotor stimulation. Our results suggest the existence of interaction between ethanol and the NMDA receptor complex in mediation of locomotor stimulation Alternatively, a common neurotransmitter system (other than glutamatergic) mediate central stimulatory effects of ethanol and dizocilpine. A possible role of dopamine in this interaction is being discussed. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 21:22:22