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Titolo:
DISCRIMINATIVE STIMULUS PROPERTIES OF ETHANOL IN THE RAT - DIFFERENTIAL-EFFECTS OF SELECTIVE AND NONSELECTIVE BENZODIAZEPINE RECEPTOR AGONISTS
Autore:
BIENKOWSKI P; IWINSKA K; STEFANSKI R; KOSTOWSKI W;
Indirizzi:
INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST,AL SOBIESKIEGO 1-9 PL-02957 WARSAW POLAND INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST PL-02957WARSAW POLAND WARSAW MED UNIV,DEPT EXPT & CLIN PHARMACOL PL-00927 WARSAW POLAND NIDA,PRECLIN PHARMACOL LAB,BEHAV PHARMACOL & GENET SECT BALTIMORE MD 21224
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 58, anno: 1997,
pagine: 969 - 973
SICI:
0091-3057(1997)58:4<969:DSPOEI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GATED ION CHANNELS; DRUG DISCRIMINATION; NMDA ANTAGONISTS; SUBSTITUTION; ABECARNIL; SUBTYPES; LIGANDS;
Keywords:
ETHANOL; GABA(A) RECEPTOR COMPLEX; BENZODIAZEPINE RECEPTOR; DRUG DISCRIMINATION; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
P. Bienkowski et al., "DISCRIMINATIVE STIMULUS PROPERTIES OF ETHANOL IN THE RAT - DIFFERENTIAL-EFFECTS OF SELECTIVE AND NONSELECTIVE BENZODIAZEPINE RECEPTOR AGONISTS", Pharmacology, biochemistry and behavior, 58(4), 1997, pp. 969-973

Abstract

Rats were trained to discriminate between ethanol (1.0 g/kg; 10% v/v)and saline under a fixed ratio 10 schedule of sweetened milk reinforcement. Both diazepam [nonselective, full benzodiazepine (BZ) receptorsagonist] and bretazenil (nonselective, partial BZ receptor agonist) produced dose-dependent ethanol-appropriate responding (>75%). Neither diazepam nor bretazenil affected the response rate at the doses producing maximal generalisation from ethanol. In contrast, zolpidem (full BZ1 receptor agonist) and abecarnil (full BZ1/full or partial BZ2 receptor agonist) produced only moderate (<50%) ethanol-appropriate responding when tested up to doses that markedly decreased the overall re sponse rate. These results suggest that: 1) there are no major differences between full and partial, nonselective BZ receptor agonists in theirability to substitute for 1.0 g/kg dose of ethanol; 2) stimulation ofBZ1 receptors alone is not sufficient to produce ethanol-like discriminative stimulus effects in the rat. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:45:45