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Titolo:
PRENATAL EXPOSURE TO NICOTINE - EFFECTS ON PREPULSE INHIBITION AND CENTRAL NICOTINIC RECEPTORS
Autore:
POPKE EJ; TIZABI Y; RAHMAN MA; NESPOR SM; GRUNBERG NE;
Indirizzi:
UNIFORMED SERV UNIV HLTH SCI,DEPT MED & CLIN PSYCHOL,4301 JONES BRIDGE RD BETHESDA MD 20814 UNIFORMED SERV UNIV HLTH SCI,DEPT MED & CLIN PSYCHOL BETHESDA MD 20814 UNIFORMED SERV UNIV HLTH SCI,NEUROSCI PROGRAM BETHESDA MD 20814 HOWARD UNIV,COLL MED,DEPT PHARMACOL WASHINGTON DC 20059
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 4, volume: 58, anno: 1997,
pagine: 843 - 849
SICI:
0091-3057(1997)58:4<843:PETN-E>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE REFLEX; CHOLINERGIC RECEPTORS; MATERNAL SMOKING; RAT-BRAIN; BINDING; PERFORMANCE; SYSTEMS; HYPERACTIVITY; REACTIVITY; MODULATION;
Keywords:
PRENATAL NICOTINE; PREPULSE INHIBITION; NICOTINIC RECEPTORS; SENSORY GATING; SEX DIFFERENCES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
E.J. Popke et al., "PRENATAL EXPOSURE TO NICOTINE - EFFECTS ON PREPULSE INHIBITION AND CENTRAL NICOTINIC RECEPTORS", Pharmacology, biochemistry and behavior, 58(4), 1997, pp. 843-849

Abstract

The present experiment examined effects of prenatal nicotine exposure(6 mg/kg/day via osmotic minipump) throughout gestation on prepulse inhibition of the acoustic startle response (PPI) and on the density ofnicotinic acetylcholine receptors (nAchRs) in the brains of 5-week-old Sprague-Dawley rats. A total of 117 male and 103 female offspring were used. Pre natal nicotine reduced subsequent percent PPI to a 98 dB stimulus in female but not in male offspring. There was an inverse correlation between the percent of PPI and nAchR density in the cortex ofmale rats and the striatum of female rats. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:51:09