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Titolo:
NON-HODGKINS-LYMPHOMA AMONG PEOPLE WITH AIDS - INCIDENCE, PRESENTATION AND PUBLIC-HEALTH BURDEN
Autore:
COTE TR; BIGGAR RJ; ROSENBERG PS; DEVESA SS; PERCY C; YELLIN FJ; LEMP G; HARDY C; GEODERT JJ; BLATTNER WA; WEST D; SINGLETON J; YOUNG J; KERNDT P; DEAPEN D; GINZBERG M; ANTONCULVER H; LIEB S; HOPKINS R; WILLIAMS B; LIFF J; MORGAN D; PARKIN W;
Indirizzi:
EPN 434,6130 EXECUT BLVD ROCKVILLE MD 20852 NCI,VIRAL EPIDEMIOL BRANCH,DIV CANC ETIOL ROCKVILLE MD 00000 NCI,BIOSTAT BRANCH,DIV CANC ETIOL ROCKVILLE MD 00000 NCI,CANC STAT BRANCH,DIV CANC PREVENT & CONTROL ROCKVILLE MD 00000 ATLANTIC RES CORP ROCKVILLE MD 00000 SAN FRANCISCO DEPT PUBL HLTH,DIV HIV AIDS SAN FRANCISCO CA 00000
Titolo Testata:
International journal of cancer
fascicolo: 5, volume: 73, anno: 1997,
pagine: 645 - 650
SICI:
0020-7136(1997)73:5<645:NAPWA->2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; RISK; DIAGNOSES; DISEASES; CANCERS; MEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
T.R. Cote et al., "NON-HODGKINS-LYMPHOMA AMONG PEOPLE WITH AIDS - INCIDENCE, PRESENTATION AND PUBLIC-HEALTH BURDEN", International journal of cancer, 73(5), 1997, pp. 645-650

Abstract

We describe the anatomic and histologic presentation and prognosis ofnon-Hodgkin's lymphoma (NHL) among people with AIDS (PWA) and determine their contribution to the NHL burden. We linked AIDS and cancer registries in selected areas of the United States and compared NHL sites and histologies in PWA and non-PWA, after adjusting for age, sex and ethnicity. Among 51,033 PWA, we found 2,156 cases of NHL (4.3%). Half of NHL cases occurring post-AIDS were not reported to AIDS registries. NHL was part of an AIDS-defining condition for 3.2% of all PWA; the relative risk of NHL with 3.5 years of another AIDS diagnosis was 165-fold compared to non-PWA within the cancer surveillance system. Of NHLs,39% were high grade (vs. 12% among non-PWA), 60% were nodal (vs. 74% among non-PWA) and 15% had brain primaries (vs. 1% among non-PWA). Excluding brain sites, extranodal sites were still 20% more common than expected. Relative risk was elevated for all histologic types, with therisk ranging from 652-fold for high-grade diffuse immunoblastic tumors and 261-fold for Burkitt's lymphomas to 113 for intermediate-grade lymphoma to 14-fold for low-grade lymphoma. Survival among PWA with NHLwas poor, and tumor grade had little impact. In high-risk AIDS areas,AIDS-related NHLs constitute a major share of the NHL burden. We conclude that NHL risk is considerably under-estimated in AIDS registry data. The major differences between PWA and non-PWA were the high frequency of brain lymphoma and the increase in high-grade lymphomas in PWA. However, the grade of NHL did not influence the prognosis among PWA with lymphoma. The increasing risk of NHL in PWA has contributed substantially to the general increase in NHL rates in the United States since 1981. (C) 1997 Wiley-Liss, Inc.

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Documento generato il 04/12/20 alle ore 18:26:59