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Titolo:
NITRIC-OXIDE SYNTHASE IMMUNOREACTIVE NERVES IN RAT AND FERRET SALIVARY-GLANDS, AND EFFECTS OF DENERVATION
Autore:
ALM P; EKSTROM J; LARSSON B; TOBIN G; ANDERSSON KE;
Indirizzi:
LUND UNIV,DEPT PATHOL S-22100 LUND SWEDEN LUND UNIV,DEPT CLIN PHARMACOL S-22100 LUND SWEDEN GOTHENBURG UNIV,DEPT PHARMACOL S-41124 GOTHENBURG SWEDEN
Titolo Testata:
Histochemical Journal
fascicolo: 9, volume: 29, anno: 1997,
pagine: 669 - 676
SICI:
0018-2214(1997)29:9<669:NSINIR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL PEPTIDE; AUTONOMIC NERVOUS-SYSTEM; PAROTID ACINAR GRANULES; SUBMANDIBULAR-GLAND; SUBSTANCE-P; REFLEX SECRETION; NADPH-DIAPHORASE; CONSCIOUS RATS; NEUROPEPTIDE-Y; L-ARGININE;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
P. Alm et al., "NITRIC-OXIDE SYNTHASE IMMUNOREACTIVE NERVES IN RAT AND FERRET SALIVARY-GLANDS, AND EFFECTS OF DENERVATION", Histochemical Journal, 29(9), 1997, pp. 669-676

Abstract

Nitric oxide has been implicated in mechanisms mediating nerve-evokedvasodilatory and secretory responses in salivary glands. In the present study, the occurrence and distribution of nitric oxide synthase (NOS)-immunoreactive nerves in ferret and rat salivary glands were investigated using immunocytochemistry with rabbit and sheep NOS antisera, and using NADPH-diaphorase enzyme histochemistry. In the parotid, submandibular and sublingual glands of the rat and the ferret, NOS-immunoreactive varicose terminals encircled acini and arteries of various sizes. In the ferret, collecting ducts were also supplied with NOS-immunoreactive fibres. In the rat, only the granular ducts of the submandibular gland were supplied with such fibres. The NOS-immunoreactive innervation of acinar cells was more abundant in the rat than in the ferret,whereas the opposite was true for the innervation of blood vessels. No NOS immunoreactivity was observed in the vascular endothelium. In both species, NOS-positive ganglionic cell bodies were found in the hilar regions of the submandibular and sublingual glands, whereas none could be detected in the parotid glands. NADPH-diaphorase reactivity had the same neuronal distribution as NOS immunoreactivity and, in addition, NADPH-diaphorase reactivity was expressed in ductal epithelium. Neither sympathetic denervation (by removal of the superior cervical ganglion) nor treatment with the sensory neurotoxin capsaicin reduced the NOS-immunoreactive innervation of the parotid gland. However, parasympathetic denervation (by cutting the auriculo-temporal nerve) caused analmost total disappearance of the NOS-immunoreactive innervation. Thepresent findings provide a morphological background to the suggested role of nitric oxide in parasympathetic secretory and vascular responses of salivary glands.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 23:03:55