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Titolo:
EFFECTS OF PHARMACOLOGICAL INCREASES IN BRAIN GABA LEVELS ON COCAINE-INDUCED CHANGES IN EXTRACELLULAR DOPAMINE
Autore:
MORGAN AE; DEWEY SL;
Indirizzi:
BROOKHAVEN NATL LAB,DEPT CHEM UPTON NY 11973 BROOKHAVEN NATL LAB,DEPT CHEM UPTON NY 11973
Titolo Testata:
Synapse
fascicolo: 1, volume: 28, anno: 1998,
pagine: 60 - 65
SICI:
0887-4476(1998)28:1<60:EOPIIB>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; RAT NUCLEUS-ACCUMBENS; INDUCED LOCOMOTOR-ACTIVITY; RECEPTOR-BINDING SITES; SUBSTANTIA-NIGRA; POTASSIUM CONDUCTANCE; D2 RECEPTORS; NEURONS; BEHAVIOR; ACID;
Keywords:
COCAINE; MICRODIALYSIS; GAMMA-VINYL-GABA; VIGABATRIN; NUCLEUS ACCUMBENS; DOPAMINE; GABA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
A.E. Morgan e S.L. Dewey, "EFFECTS OF PHARMACOLOGICAL INCREASES IN BRAIN GABA LEVELS ON COCAINE-INDUCED CHANGES IN EXTRACELLULAR DOPAMINE", Synapse, 28(1), 1998, pp. 60-65

Abstract

Cocaine-induced increases in extracellular dopamine (DA) concentrations were measured using in vivo microdialysis techniques in the nucleusaccumbens (NACC) of freely moving rats. In control animals, cocaine increased extracellular DA concentrations approximately 482% 60 min following administration, returning to baseline values 200 min later. When administered 2 h following an acute dose of gamma-vinyl-GABA (GVG, Vigabatrin), cocaine-induced increases in extracellular DA were reducedto approximately 365% of baseline values. Chronic GVG administration further dose-dependently attenuated the effects of cocaine but did notalter the rate of increase or the rate of return to baseline values. These results indicate that GVG, a drug that increases brain GABA concentrations! is effective in attenuating the effect of cocaine on NACC DA. Taken with our earlier findings, these results support the targeting of brain GABAergic systems as a potentially effective pharmacologictreatment strategy for cocaine addiction. (C) 1998 Wiley-Liss, Inc.(dagger)

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Documento generato il 27/01/20 alle ore 01:21:24