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Titolo:
LAYER-V NEURONS BEAR THE MAJORITY OF MESSENGER-RNAS ENCODING THE 5 DISTINCT DOPAMINE-RECEPTOR SUBTYPES IN THE PRIMATE PREFRONTAL CORTEX
Autore:
LIDOW MS; WANG F; CAO Y; GOLDMANRAKIC PS;
Indirizzi:
UNIV MARYLAND,DEPT ORAL & CRANIOFACIAL BIOL SCI,5-A-12,HHH BALTIMORE MD 21201 YALE UNIV,SCH MED,NEUROBIOL SECT NEW HAVEN CT 06510
Titolo Testata:
Synapse
fascicolo: 1, volume: 28, anno: 1998,
pagine: 10 - 20
SICI:
0887-4476(1998)28:1<10:LNBTMO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSITU HYBRIDIZATION HISTOCHEMISTRY; MESSENGER-RNA; RAT-BRAIN; CEREBRAL-CORTEX; AUTORADIOGRAPHIC ANALYSIS; MOLECULAR-CLONING; D2; D1; LOCALIZATION; BINDING;
Keywords:
CEREBRAL CORTEX; STRIATUM; D1, D2, D3, D4, AND D5 DOPAMINE RECEPTORS; IN SITU HYBRIDIZATION; NORTHERN BLOT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Lidow et al., "LAYER-V NEURONS BEAR THE MAJORITY OF MESSENGER-RNAS ENCODING THE 5 DISTINCT DOPAMINE-RECEPTOR SUBTYPES IN THE PRIMATE PREFRONTAL CORTEX", Synapse, 28(1), 1998, pp. 10-20

Abstract

In situ hybridization histochemistry was used to determine the laminar distribution of D1, D2, D3, D4, and D5 dopamine receptor mRNAs In the primate prefrontal cortex and to compare striatal and cortical levels of these messages within the same tissue sections. All five subtypesof dopamine receptor mRNA are present in both the monkey striatum andthe cerebral cortex but in different proportions within each structure. Thus, levels of D1 and D2 mRNAs are noticeably stronger in the striatum than in the cortex, whereas D4 and D5 expression is clearly higher in the cortex. The D3 transcripts appear nearly equivalent in the striatum and the cortex, A major finding is that, within the prefrontal cortex, mRNAs encoding all dopamine receptor subtypes are expressed most strongly in layer V. This laminar pattern of mRNA distribution doesnot hold in all cortical regions. The relatively high levels of mRNAsencoding known dopamine receptor subtypes in the primate cerebral cortex, including the D3 receptor, underscore the importance of this structure as a target for therapeutic actions of antipsychotic drugs. Further, their prominence in layer V of the prefrontal cortex, which contains the corticostriatal and corticotectal projection neurons, providesa neural basis for dopaminergic regulation of the descending control systems. (C) 1998 Wileg-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:45:09