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Titolo:
EPITHELIAL MEMBRANE ANTIGEN IN HEMATOLYMPHOID NEOPLASMS - A REVIEW
Autore:
CHITTAL S; ALSAATI T; DELSOL G;
Indirizzi:
CHU PURPAN,ANAT PATHOL LAB,DEPT PATHOL,PL DOCTEUR BAYLAC F-31059 TOULOUSE FRANCE CHU PURPAN,ANAT PATHOL LAB,DEPT PATHOL F-31059 TOULOUSE FRANCE CHU PURPAN,CTR IMMUNOPATHOL & GENET HUMAINE,CNRS F-31059 TOULOUSE FRANCE MEM UNIV NEWFOUNDLAND ST JOHNS NF CANADA
Titolo Testata:
Applied immunohistochemistry
fascicolo: 4, volume: 5, anno: 1997,
pagine: 203 - 215
SICI:
1062-3345(1997)5:4<203:EMAIHN>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
LARGE-CELL LYMPHOMA; MILK-FAT GLOBULE; PREDOMINANT HODGKINS-DISEASE; PARAFFIN SECTION IMMUNOHISTOCHEMISTRY; DISTINCT CLINICOPATHOLOGICAL ENTITY; T-CELL; MONOCLONAL-ANTIBODIES; MALIGNANT HISTIOCYTOSIS; BREAST-CANCER; KI-1 LYMPHOMA;
Keywords:
EPITHELIAL MEMBRANE ANTIGEN (EMA); MUC1 MUCIN; IMMUNOHISTOCHEMISTRY; HODGKINS DISEASE; NON-HODGKINS LYMPHOMA; ANAPLASTIC LARGE CELL LYMPHOMA;
Tipo documento:
Review
Natura:
Periodico
Citazioni:
151
Recensione:
Indirizzi per estratti:
Citazione:
S. Chittal et al., "EPITHELIAL MEMBRANE ANTIGEN IN HEMATOLYMPHOID NEOPLASMS - A REVIEW", Applied immunohistochemistry, 5(4), 1997, pp. 203-215

Abstract

The transmembrane glycoprotein of the breast mucin complex, or epithelial membrane antigen (EMA), is encoded by the MUC1 gene, located on chromosome 1 in 1q21-24 region. EMA expression as detected by anti-EMA antibodies is found in many epithelial cells other than the breast andits neoplasms, but the epitopes recognized are different depending onthe antibody used because of different glycosylation levels and genetic polymorphism. In hematolymphoid tissues, EMA is normally expressed by plasma cells. The expression of EMA is conserved and probably heightened in plasma cell neoplasms, whereas neoplasms from earlier stage B-cell differentiation are not usually associated with the expression of EMA. Within the lymph node-based B-cell lymphomas, the EMA is mainlyexpressed by diffuse large B-cell-and T-cell-rich B-cell lymphomas. The expression of EMA is more frequent in T-cell malignancies, occurring in about 20% of all T-cell lymphomas. The most frequent expression of EMA is recorded in lymphocytic and histiocytic cells of nodular lymphocyte predominance Hodgkin's disease (nLPHD) and in anaplastic large cell lymphomas (ALCL). EMA expression in Reed-Sternberg cells of classic Hodgkin's disease (HD) is unusual. Although the differential expression of EMA within lymphoid neoplasms may be of diagnostic assistance,clear biologic significance of EMA expression or MUC1 gene activationin lymphomas has yet to emerge. To this end, it is important to studythe patterns of activation of the MUC1 gene by different antibodies and correlate the differential glycosylation of the core proteins with biologic behavior of lymphoid neoplasms, as is being currently attempted for neoplasms of the glandular epithelium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:51:34