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Titolo:
LIPOPOLYSACCHARIDE DECREASES SCAVENGER RECEPTOR MESSENGER-RNA IN-VIVO
Autore:
ROSELAAR SE; DAUGHERTY A;
Indirizzi:
UNIV KENTUCKY,DIV CARDIOVASC MED,KENTUCKY CLIN,ROOM L-543,740 LIMESTONE ST LEXINGTON KY 40536 WASHINGTON UNIV,SCH MED,DEPT MED,DIV CARDIOVASC ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT BIOCHEM & MOL BIOPHYS ST LOUIS MO 63110
Titolo Testata:
Journal of interferon & cytokine research
fascicolo: 9, volume: 17, anno: 1997,
pagine: 573 - 579
SICI:
1079-9907(1997)17:9<573:LDSRMI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; LOW-DENSITY-LIPOPROTEIN; HUMAN MONOCYTE-MACROPHAGES; SMOOTH-MUSCLE CELLS; HERITABLE HYPERLIPIDEMIC RABBITS; INTERFERON-GAMMA RECEPTOR; FACTOR-ALPHA; CHOLESTEROL DEPOSITION; BINDING-PROPERTIES; MESSENGER-RNA;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
S.E. Roselaar e A. Daugherty, "LIPOPOLYSACCHARIDE DECREASES SCAVENGER RECEPTOR MESSENGER-RNA IN-VIVO", Journal of interferon & cytokine research, 17(9), 1997, pp. 573-579

Abstract

Lipopolysaccharide (LPS) downregulates scavenger receptor (ScR) activity in cultured macrophages through release of tumor necrosis factor-alpha (TNF-alpha), However, LPS administration in vivo stimulates cytokine release from both macrophages and lymphocytes, the combined effects of which could alter ScR expression differently from TNF-alpha in isolation, To investigate whether LPS regulates ScR in vivo, 10 mu g/g was injected i.p. into Swiss Webster mice, Administration of LPS produced a profound decrease in hepatic ScR mRNA, with reductions of 74% +/-8% at 2 h that returned to baseline levels by 6 h, Changes in ScR mRNA abundance coincided with changes in serum concentrations of TNF-alpha, which peaked at 2 h (1320 +/- 309 pg/ml) and returned to preinjection concentrations at 4 h, Serum concentrations of interferon-gamma (IFN-gamma) did not increase until 4 h after injection of LPS. There was no effect on ScR mRNA abundance following LPS administration to LPS-resistant strains of mice, C3H/HeJ and IFN-gamma receptor(-/-). The LPS-induced reduction in ScR mRNA in Swiss Webster mice was not sufficiently sustained to affect receptor function, as determined by the kinetics of [I-125]-acetylated LDL clearance from plasma, Therefore, as observed in cultured cells, LPS administration to mice decreases ScR mRNA despite the release of several cytokines in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 15:39:12