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Titolo:
SUBLETHAL GAMMA-IRRADIATION INCREASES IL-1-ALPHA, IL-6, AND TNF-ALPHAMESSENGER-RNA LEVELS IN MURINE HEMATOPOIETIC TISSUES
Autore:
CHANG CM; LIMANNI A; BAKER WH; DOBSON ME; KALINICH JF; PATCHEN ML;
Indirizzi:
ARMED FORCES RADIOBIOL RES INST,DEPT RADIAT MED,8901 WISCONSIN AVE BETHESDA MD 20889 ARMED FORCES RADIOBIOL RES INST,DEPT APPL CELLULAR RADIOBIOL BETHESDAMD 20889
Titolo Testata:
Journal of interferon & cytokine research
fascicolo: 9, volume: 17, anno: 1997,
pagine: 567 - 572
SICI:
1079-9907(1997)17:9<567:SGIIIA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; COLONY-STIMULATING FACTOR; TOTAL-BODY IRRADIATION; GENE-EXPRESSION; IONIZING-RADIATION; INTERLEUKIN-1 IL-1; LETHAL IRRADIATION; MESSENGER-RNA; BONE-MARROW; MICE;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
C.M. Chang et al., "SUBLETHAL GAMMA-IRRADIATION INCREASES IL-1-ALPHA, IL-6, AND TNF-ALPHAMESSENGER-RNA LEVELS IN MURINE HEMATOPOIETIC TISSUES", Journal of interferon & cytokine research, 17(9), 1997, pp. 567-572

Abstract

The effects of sublethal (7.75 Gy) Co-60 gamma radiation exposure on endogenous bone marrow and splenic interleukin-1 alpha (IL-1 alpha), IL-6, and tumor necrosis factor-alpha (TNF-alpha) mRNA and protein levels were assayed in B6D2F1 female mice, Bone marrow and spleen were harvested from normal and irradiated mice on days 2, 4, 7, 10, and 14 postexposure, and cytokine mRNA levels were determined by reverse transcription polymerase chain reaction (RT-PCR) and Southern blot analysis, IL-1 alpha mRNA levels were significantly increased in bone marrow at days 2 and 4 postirradiation and at day 7 in spleen compared with controls, Postirradiation IL-6 mRNA levels showed a significant increase at day 2 in bone marrow and at days 7 and 10 in spleen, TNF-alpha mRNA levels exhibited a significant increase at day 2 postirradiation in bone marrow, but in spleen no difference between control and irradiated samples was observed on any day postirradiation, Interestingly, there were no significant differences in the cytokine protein levels in postirradiation bone marrow, spleen, or serum when compared with normal controls.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:39:45