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Titolo:
FLUOXETINE INCREASES NOREPINEPHRINE RELEASE IN RAT HYPOTHALAMUS AS MEASURED BY TISSUE-LEVELS OF MHPG-SO4 AND MICRODIALYSIS IN CONSCIOUS RATS
Autore:
PERRY KW; FULLER RW;
Indirizzi:
ELI LILLY & CO,LILLY CORP CTR,LILLY RES LABS,CENT NERVOUS SYST RES INDIANAPOLIS IN 46285
Titolo Testata:
Journal of neural transmission
fascicolo: 8-9, volume: 104, anno: 1997,
pagine: 953 - 966
SICI:
0300-9564(1997)104:8-9<953:FINRIR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN UPTAKE INHIBITOR; VENTRAL TEGMENTAL AREA; LOCUS COERULEUS; ENDOGENOUS NOREPINEPHRINE; EXTRACELLULAR SEROTONIN; NORADRENERGIC NEURONS; PREFRONTAL CORTEX; RAPHE-DORSALIS; 5-HT RECEPTORS; EVOKED RELEASE;
Keywords:
FLUOXETINE; RAT; HYPOTHALAMUS; NOREPINEPHRINE; MICRODIALYSIS; BRAIN; MHPG; DESIPRAMINE; DMI; HPLC-EC;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
K.W. Perry e R.W. Fuller, "FLUOXETINE INCREASES NOREPINEPHRINE RELEASE IN RAT HYPOTHALAMUS AS MEASURED BY TISSUE-LEVELS OF MHPG-SO4 AND MICRODIALYSIS IN CONSCIOUS RATS", Journal of neural transmission, 104(8-9), 1997, pp. 953-966

Abstract

The selective serotonin uptake inhibitor fluoxetine (10 mg/kg i.p) increased tissue levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylethylene glycol sulfate (MHPG-SO,) in rat hypothalamus, indicating an increased release of norepinephrine. Microdialysis studies in conscious rats showed that fluoxetine (10 mg/kg i.p.) increased extracellular concentrations of norepinephrine as well as serotonin in thehypothalamus. In contrast, desipramine (10 mg/kg i.p.) increased extracellular concentration of norepinephrine but not serotonin in the hypothalamus. Consistent with its mechanism of being a selective serotonin uptake inhibitor, local perfusion of fluoxetine (10 mu M) caused a 7-fold increase in hypothalamic extracellular serotonin and a small non-significant increase in extracellular norepinephrine. The subsequent systemic injection of fluoxetine (10 mg/kg s.c.) after local perfusioncaused a 3-fold increase in extracellular norepinephrine, indicating that fluoxetine's action leading to an increase in extracellular norepinephrine was not occurring in the terminal areas of the hypothalamus but elsewhere in the brain, possibly cell bodies in the locus coeruleus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 07:43:08