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Titolo:
HIGH-AFFINITY [3H]IMIPRAMINE AND [3H]PAROXETINE BINDING-SITES IN SUICIDE BRAINS
Autore:
ROSEL P; ARRANZ B; VALLEJO J; OROS M; MENCHON JM; ALVAREZ P; NAVARRO MA;
Indirizzi:
HOSP PRINCEPS ESPANYA,DEPT CLIN CHEM,HORMONE UNIT,FEIXA LLARGA S-N E-08907 LHOSPITALET LLOBR BARCELONA SPAIN HOSP PRINCEPS ESPANYA,DEPT BIOCHEM,HORMONE UNIT BARCELONA SPAIN CASM,BENITO MENNI BARCELONA SPAIN HOSP PRINCEPS ESPANYA,DEPT PSYCHIAT BARCELONA SPAIN
Titolo Testata:
Journal of neural transmission
fascicolo: 8-9, volume: 104, anno: 1997,
pagine: 921 - 929
SICI:
0300-9564(1997)104:8-9<921:H[A[BI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 PAROXETINE BINDING; 5-HYDROXYTRYPTAMINE-SENSITIVE )H-3>IMIPRAMINE BINDING; 5-HT UPTAKE SITES; RAT-BRAIN; REGIONAL DISTRIBUTION; IMIPRAMINE BINDING; FRONTAL-CORTEX; PROTEIN NATURE; PLATELETS; DEPRESSION;
Keywords:
[3H]IMIPRAMINE; [3H]PAROXETINE; HUMAN BRAIN; DEPRESSION; SUICIDE;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
P. Rosel et al., "HIGH-AFFINITY [3H]IMIPRAMINE AND [3H]PAROXETINE BINDING-SITES IN SUICIDE BRAINS", Journal of neural transmission, 104(8-9), 1997, pp. 921-929

Abstract

Specific binding of [3H]imipramine and [3H]paroxetine was simultaneously examined in human brains (frontal cortex, temporal cortex, cingulate cortex, hypothalamus, hippocampus and amygdala) from 11 controls and 11 depressed suicide victims. A single saturable high affinity site was obtained for both radioligands. Age was not related to significantchanges in [3H]imipramine and [3H]paroxetine binding parameters, which indicates the stability of the brain serotonergic system with increasing age. A major finding of the present study concerns the existence of a significant decrease in the maximum number (Bmax) of [3H]imipramine binding sites in hippocampus from depressed suicides as compared with the control group, without changes in the binding affinity (Kd). Incontrast, when [3H]paroxetine was used as radioligand, no changes in either Bmax or Kd were detected in any of the brain regions studied. These findings suggest that [3H]imipramine may be a better marker than [3H]paroxetine when alterations in the presynaptic serotonergic uptakesite are to be detected.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:35:15