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Titolo:
INCREASED EXPRESSION OF MICROTUBULE-ASSOCIATED PROTEIN 1B IN THE HIPPOCAMPUS, SUBICULUM, AND PERFORANT PATH OF RATS TREATED WITH A HIGH-DOSE OF PENTYLENETETRAZOLE
Autore:
POPAWAGNER A; FISCHER B; SCHMOLL H; PLATT D; KESSLER C;
Indirizzi:
UNIV GREIFSWALD,DEPT NEUROL GREIFSWALD GERMANY UNIV ERLANGEN NURNBERG,INST GERONTOL NURNBERG GERMANY
Titolo Testata:
Experimental neurology
fascicolo: 1, volume: 148, anno: 1997,
pagine: 73 - 82
SICI:
0014-4886(1997)148:1<73:IEOMP1>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL-LOBE EPILEPSY; FACTOR MESSENGER-RNA; DENTATE GYRUS; INDUCED SEIZURES; SYNAPTIC REORGANIZATION; INHIBITORY NEURONS; BRAIN; CELLS; STIMULATION; LOCALIZATION;
Keywords:
MICROTUBULE-ASSOCIATED PROTEIN 1B (MAP1B); HIPPOCAMPUS; SUBICULUM; PERFORANT PATH; PENTYLENETETRAZOLE; SEIZURE; RATS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
A. Popawagner et al., "INCREASED EXPRESSION OF MICROTUBULE-ASSOCIATED PROTEIN 1B IN THE HIPPOCAMPUS, SUBICULUM, AND PERFORANT PATH OF RATS TREATED WITH A HIGH-DOSE OF PENTYLENETETRAZOLE", Experimental neurology, 148(1), 1997, pp. 73-82

Abstract

A single administration of the convulsant pentylenetetrazole (PTZ) initiates a complex pattern of longterm changes in microtubule-associated protein 1B (MAP1B) expression across the hippocampal formation. Using Northern blot and in situ hybridization we show that the first increases in MAP1B mRNA were detected at 15 h following PTZ administration in the granule cells of the dentate gyrus and CA3 region of the hippocampus and reached a maximum at 44 h. The levels of MAP1B mRNA in the subiculum peaked at later times (5 days). At 72 h MAP1B immunoreactivity was mainly localized in the granule-cell bodies and dentate inner and midmolecular layer as well as in neuronal cell bodies and the stratum lucidum, including the messy fiber pathway of the CA3 region. By 5-10 days the levels of MAP1B in the pyramidal cells in the CA3 region decreased to very low levels; rather, heavy staining of interneuron-likecells and ''strings-of-bead'' structures all over the hippocampus andat the stratum oriens/alveus border were seen. The levels of MAP1B inthe hippocampus returned to control levels by 20 days after PTZ administration. MAP1B immuno-reactivity in the alvear path was also evidentat 5 days postinjection at the CA1/alveus border. The intensity of MAP1B staining increased gradually in the perforant path starting at 72 h and persisted at high levels until day 35. Our studies show that (i)MAP1B is a temporal and regional marker for rapid and acute epilepticseizures and (ii) long-term increases in MAP1B in the perforant path might play a role in PTZ-induced seizures. (C) 1997 Academic Press.

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Documento generato il 25/01/20 alle ore 18:53:47