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Titolo:
GROWTH-HORMONE SECRETAGOGUES IN CHILDREN WITH ALTERED GROWTH
Autore:
BERCU BB; WALKER RF;
Indirizzi:
UNIV S FLORIDA,ALL CHILDRENS HOSP,DIV ENDOCRINOL & DIABET,BOX 6900,801 6TH ST S ST PETERSBURG FL 33701 UNIV S FLORIDA,ALL CHILDRENS HOSP,DEPT PEDIAT,COLL MED ST PETERSBURG FL 33701 UNIV S FLORIDA,ALL CHILDRENS HOSP,DIV ENDOCRINOL DIABET & METAB,COLL MED ST PETERSBURG FL 33701 UNIV S FLORIDA,ALL CHILDRENS HOSP,DIV SPONSORED RES,COLL MED ST PETERSBURG FL 33701 UNIV S FLORIDA,ALL CHILDRENS HOSP,DEPT PHARMACOL & THERAPEUT,COLL MEDST PETERSBURG FL 33701 UNIV S FLORIDA,ALL CHILDRENS HOSP,DEPT BIOCHEM & MOL BIOL,COLL MED STPETERSBURG FL 33701
Titolo Testata:
Acta paediatrica
, volume: 86, anno: 1997, supplemento:, 423
pagine: 102 - 106
SICI:
0803-5253(1997)86:<102:GSICWA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
GH-RELEASING HORMONE; PITUITARY; HEXAPEPTIDE; SECRETION; PEPTIDE; GHRP-6;
Keywords:
DIAGNOSTIC TEST; GROWTH HORMONE-RELEASING HORMONE; GROWTH HORMONE-RELEASING PEPTIDE; GROWTH HORMONE SECRETAGOGUES;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
B.B. Bercu e R.F. Walker, "GROWTH-HORMONE SECRETAGOGUES IN CHILDREN WITH ALTERED GROWTH", Acta paediatrica, 86, 1997, pp. 102-106

Abstract

A diagnostic test was devised to evaluate pituitary growth hormone (GH) secretory potential. GH secretory dynamics were assessed in children with and without GH deficiency. The GH response was measured to GH-releasing hormone (GHRH) and the GH-releasing peptide GHRP-2, administered sequentially. The mean (+/- SEM) peak GH response to GHRP-2 was 20.1 +/- 5.5, 63.6 +/- 24.9 and 42.2 +/- 4.3 mu g/l for GH-deficient, slowly growing non-GH-deficient and control children, respectively (p < 0.02 and p < 0.05 for GH-deficient vs controls and slowly growing children, respectively). Corresponding values for area under the curve (AUC) were 995 +/- 371, 2460 +/- 953 and 1598 +/- 274 mu g/l x minute. Peak GH (and AUC) responses to GHRH were 19.6 +/- 5.1 mu g/l (924 +/- 232 mu g/l x minute), 31.4 +/- 8.4 mu g/l (1544 +/- 449 mu g/l x minute)and 39.8 +/- 7.8 mu g/l (2201 +/- 437 mu g/l x minute) for the same three groups, respectively (p < 0.05 for peak GH in GH-deficient patients vs controls, and p < 0.02 and p < 0.01 for AUC in GH-deficient vs slowly growing children and controls, respectively). The ratio of the peak GH response to GHRP-2 and GHRH was similar in all three groups. Asthese secretagogues stimulate different aspects of hypothalamic function (i.e., they are functional complements), robust GH secretion in response to GHRH or GHRP could suggest adequate endogenous GHRP or GHRH,respectively. A poor response to either GH secretagogue administered individually could represent inadequacy of its endogenous complement. The integrity of functional pituitary elements could be differentiatedfrom inadequate complements by administering both GH secretagogues simultaneously. Application of these principles should allow a better definition of the underlying disorder and provide the basis for therapeutic strategies for those patients with abnormal GH production and/or secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:50:40