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Titolo:
GROWTH-HORMONE SECRETAGOGUES IN PATHOLOGICAL STATES - DIAGNOSTIC IMPLICATIONS
Autore:
POPOVIC V; MICIC D; DAMJANOVIC S; OBRADOVIC S; DJUROVIC M; PETAKOV M; GRUDIC D; GOLUBICIC I; NIKITOVIC M; MITROVIC N; DIEGUEZ C; CASANUEVA FF;
Indirizzi:
UNIV BELGRADE,INST ENDOCRINOL,CTR CLIN,KARNEGIJEVA 4 YU-11000 BELGRADE YUGOSLAVIA INST ONCOL & RADIOL BELGRADE YUGOSLAVIA UNIV SANTIAGO DE COMPOSTELA,FAC MED,DEPT PHYSIOL SANTIAGO COMPOSTE SPAIN UNIV SANTIAGO DE COMPOSTELA,FAC MED,DEPT MED SANTIAGO COMPOSTE SPAIN
Titolo Testata:
Acta paediatrica
, volume: 86, anno: 1997, supplemento:, 423
pagine: 97 - 101
SICI:
0803-5253(1997)86:<97:GSIPS->2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCYSTIC-OVARY-SYNDROME; GH-RELEASING HORMONE; SECRETION; GHRP-6; DEFICIENCY; ADULTS; PITUITARY; HEXAPEPTIDE; RESPONSES; RECEPTOR;
Keywords:
GROWTH HORMONE-RELEASING PEPTIDE-6; GROWTH HORMONE-RELEASING HORMONE; HEXARELIN; METABOLIC DERANGEMENTS; NEUROENDOCRINE PATHOLOGIES;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
V. Popovic et al., "GROWTH-HORMONE SECRETAGOGUES IN PATHOLOGICAL STATES - DIAGNOSTIC IMPLICATIONS", Acta paediatrica, 86, 1997, pp. 97-101

Abstract

The identification and cloning of the receptor for synthetic growth hormone (GH) secretagogues, even before the endogenous ligand has been identified or its precise physiological role established, suggests that there in a novel target of action for this class of drug. In an attempt to select patients who will benefit from GH treatment, GH secretagogues are being evaluated for their usefulness in diagnosing GH deficiency. The effects of GH-releasing peptides (GHRPs) on GH release as a function of age and metabolic status, and in different neuroendocrine pathologies, are described, as are the different mechanisms of action,potency and reproducibility of the response to GHRPs compared with GH-releasing hormone (GHRH). GHRPs offer the advantage over GHRH in natural models of deranged GH secretion in that, in Various metabolic states (e.g., obesity, anorexia nervosa and non-insulin-dependent diabetesmellitus), the GH response to GHRH is more impaired than it is to GHRPs. However, in some neuroendocrine pathologies, the reverse is true. Thus, both secretagogues provide separate information on the physiological status of somatotrophs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:48:12