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Titolo:
THE DEVELOPMENT OF IMPERVIOUS PEPTIDES AS GROWTH-HORMONE SECRETAGOGUES
Autore:
DEGHENGHI R;
Indirizzi:
EUROPEPTIDES,9 AVE DU MARAIS F-95100 ARGENTEUIL FRANCE
Titolo Testata:
Acta paediatrica
, volume: 86, anno: 1997, supplemento:, 423
pagine: 85 - 87
SICI:
0803-5253(1997)86:<85:TDOIPA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR; IDENTIFICATION; RELEASE;
Keywords:
GROWTH HORMONE SECRETAGOGUES; GROWTH HORMONE-RELEASING PEPTIDE; HEXARELIN;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
R. Deghenghi, "THE DEVELOPMENT OF IMPERVIOUS PEPTIDES AS GROWTH-HORMONE SECRETAGOGUES", Acta paediatrica, 86, 1997, pp. 85-87

Abstract

The discovery and development of growth hormone (GH) secretagogues isbriefly reviewed. GH-releasing peptide-6 (GHRP-6) was the first GHRP to be developed that was active in vivo. Smaller peptides were found to have no GH-releasing activity in vivo, even though they were potent releasers of GH in vitro. Substituting Trp with 2-Me-Trp led to the development of orally active hexarelin and other, smaller, peptides. Although they showed oral activity, absorption rarely exceeded 1% of the administered dose. Nonpeptide GH secretagogues have now been developedthat combine reasonable oral absorption with high potency. The next development will be to produce GH secretagogues that overcome the lack of specificity shown by the present molecules.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:19:40