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Titolo:
NEUROPHARMACOLOGICAL ASSESSMENT OF GROWTH-HORMONE SECRETION
Autore:
CARRO E; SENARIS R; PEINO R; LEALCERRO A; POPOVIC V; MICIC D; DIEGUEZ C; CASANUEVA FF;
Indirizzi:
POB 563 E-15780 SANTIAGO COMPOSTE SPAIN UNIV SANTIAGO DE COMPOSTELA,COMPLEJO HOSP SANTIAGO,DEPT PHYSIOL SANTIAGO COMPOSTE SPAIN UNIV SANTIAGO DE COMPOSTELA,COMPLEJO HOSP SANTIAGO,DEPT MED SANTIAGO COMPOSTE SPAIN HOSP VIRGEN DEL ROCIO,DIV ENDOCRINOL SEVILLE SPAIN UNIV BELGRADE,CTR CLIN YU-11000 BELGRADE YUGOSLAVIA
Titolo Testata:
Acta paediatrica
, volume: 86, anno: 1997, supplemento:, 423
pagine: 12 - 16
SICI:
0803-5253(1997)86:<12:NAOGS>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GH-RELEASING HORMONE; FREE FATTY-ACIDS; PITUITARY; GHRP-6; SOMATOSTATIN; DEFICIENCY; ADULTHOOD; RESPONSES; CHILDREN; OBESITY;
Keywords:
GROWTH HORMONE-RELEASING HORMONE; SOMATOSTATIN; GROWTH HORMONE SECRETAGOGUE; GROWTH HORMONE-RELEASING PEPTIDE-6;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
E. Carro et al., "NEUROPHARMACOLOGICAL ASSESSMENT OF GROWTH-HORMONE SECRETION", Acta paediatrica, 86, 1997, pp. 12-16

Abstract

The biochemical diagnosis of individuals who are either deficient in growth hormone (GH) or who have alterations in the normal pattern of GH secretion is difficult. The uncertainty surrounding diagnosis reflects the lack of a thorough understanding of the physiology of GH secretion and of the hypothalamic hormones involved. At least three hormonesare implicated: GH-releasing hormone (GHRH), somatostatin and the endogenous ligand of the GH secretagogue receptor, although the role thateach plays in the release of GH is not clear from the available experimental evidence. In such a situation, most of the dynamic tests of GHsecretory capacity in humans need to undergo a 'trial and error' process before being validated. The search for the 'gold standard' test ofGH secretion is ongoing, and the combination of GHRH plus GK secretagogues will probably play an important role in future clinical diagnosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:07:04