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Titolo:
KIDNEY-SPECIFIC EXPRESSION OF A NOVEL MOUSE ORGANIC CATION TRANSPORTER-LIKE PROTEIN
Autore:
MORI K; OGAWA Y; EBIHARA K; AOKI T; TAMURA N; SUGAWARA A; KUWAHARA T; OZAKI S; MUKOYAMA M; TASHIRO K; TANAKA I; NAKAO K;
Indirizzi:
KYOTO UNIV,GRAD SCH MED,DEPT MED & CLIN SCI KYOTO 606 JAPAN KYOTO UNIV,GRAD SCH MED,DEPT MED & CLIN SCI KYOTO 606 JAPAN KYOTO UNIV,CTR MOL BIOL & GENET KYOTO 606 JAPAN SAISEIKAI NAKATSU HOSP,DEPT NEPHROL OSAKA 530 JAPAN
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 417, anno: 1997,
pagine: 371 - 374
SICI:
0014-5793(1997)417:3<371:KEOANM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-CLONING; SEQUENCES; SYSTEM;
Keywords:
ORGANIC CATION TRANSPORTER; NUTRIENT TRANSPORTER; SIGNAL SEQUENCE TRAP; IN SITU HYBRIDIZATION; MOUSE KIDNEY;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
K. Mori et al., "KIDNEY-SPECIFIC EXPRESSION OF A NOVEL MOUSE ORGANIC CATION TRANSPORTER-LIKE PROTEIN", FEBS letters, 417(3), 1997, pp. 371-374

Abstract

Using the signal sequence trap method, we have cloned a novel 12-membrane-spanning transporter-like protein, termed renal-specific transporter (RST), from the mouse kidney, RST is a 553-amino-acid protein highly homologous to recently cloned organic cation transporters, e.g. it is 30% identical to rat organic cation transporter 1 at the amino acidlevel, Northern blot analysis has revealed that the RST gene is expressed abundantly and specifically in the kidney, In situ hybridization analysis has shown that RST gene expression is restricted to the renalproximal tubule, where various organic cations such as endogenous catecholamines and choline or clinically used cationic drugs are known tobe actively excreted. (C) 1997 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 17:32:51