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Titolo:
ASPIRIN PROTECTS ENDOTHELIAL-CELLS FROM OXIDATIVE STRESS - POSSIBLE SYNERGISM WITH VITAMIN-E
Autore:
PODHAISKY HP; ABATE A; POLTE T; OBERLE S; SCHRODER H;
Indirizzi:
UNIV HALLE WITTENBERG,SCH PHARM,DEPT PHARMACOL & TOXICOL,WOLFGANG LANGENBECK STR 4 D-06099 HALLE SAALE GERMANY UNIV HALLE WITTENBERG,SCH PHARM,DEPT PHARMACOL & TOXICOL D-06099 HALLE SAALE GERMANY
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 417, anno: 1997,
pagine: 349 - 351
SICI:
0014-5793(1997)417:3<349:APEFOS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTI-INFLAMMATORY DRUGS; CARDIOVASCULAR-DISEASE; AGENTS; IRON;
Keywords:
ASPIRIN; VITAMIN-E; D-ALPHA-TOCOPHEROL ACETATE; ENDOTHELIAL CELLS; CYTOPROTECTION; ANTIOXIDANT;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
H.P. Podhaisky et al., "ASPIRIN PROTECTS ENDOTHELIAL-CELLS FROM OXIDATIVE STRESS - POSSIBLE SYNERGISM WITH VITAMIN-E", FEBS letters, 417(3), 1997, pp. 349-351

Abstract

A 24-h incubation with hydrogen peroxide (0.65 mM) markedly reduced viability of cultured endothelial cells, Preincubation with aspirin (3-30 mu M) protected endothelial cells from hydrogen peroxide-induced toxicity and increased viability in a concentration-dependent fashion byup to 64% of control, A similar protection was observed with D-alpha-tocopherol acetate (vitamin E, 3-30 mu-M) The cytoprotective effects of aspirin and vitamin E against hydrogen peroxide were overadditive suggesting different mechanisms of antioxidant action, In agreement withthis, cytotoxicity induced by iron, the main catalyst of oxygen radical formation, was substantially reduced by aspirin but not vitamin E. These results show that aspirin protects endothelial cells from oxidative stress possibly via binding or chelation of free cytosolic iron, Moreover, a combination of aspirin and vitamin E might be useful for the prevention of endothelial injury in cardiovascular disease, e.g. during atherogenesis. (C) 1997 Federation of European Biochemical Societies.

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Documento generato il 09/04/20 alle ore 19:59:47