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Titolo:
Tardive dyskinesia and atypical antipsychotic drugs
Autore:
Casey, DE;
Indirizzi:
Vet Affairs Med Ctr, Div Mental Hlth, Portland, OR 97207 USA Vet Affairs Med Ctr Portland OR USA 97207 al Hlth, Portland, OR 97207 USA
Titolo Testata:
SCHIZOPHRENIA RESEARCH
, volume: 35, anno: 1999, supplemento:, S
pagine: S61 - S66
SICI:
0920-9964(19990301)35:<S61:TDAAAD>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOLLOW-UP; WEIGHT-GAIN; SCHIZOPHRENIA; CLOZAPINE; HALOPERIDOL; OLANZAPINE; PREVALENCE; RISPERIDONE; MOVEMENTS; DISORDERS;
Keywords:
atypical antipsychotics; clozapine; extrapyramidal symptoms; olanzapine; risperidone; tardive dyskinesia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Casey, DE Vetland,irs Med Ctr, Div Mental Hlth, 3710 SW US Vet Hosp Rd,P-7-MHDC, Port Vet Affairs Med Ctr 3710 SW US Vet Hosp Rd,P-7-MHDC Portland ORUSA 97207
Citazione:
D.E. Casey, "Tardive dyskinesia and atypical antipsychotic drugs", SCHIZOPHR R, 35, 1999, pp. S61-S66

Abstract

Typical antipsychotic agents produce central nervous system effects, especially extrapyramidal symptoms (EPS) and tardive dyskinesia (TD). Nearly every patient who receives neuroleptic therapy has one or more identifiable risk factors for TD, among the most significant of which are older age, female gender, presence of EPS, diabetes mellitus, affective disorders, and certain parameters of neuroleptic exposure (i.e. dose and duration of therapy). The typical course of TD is a gradual onset after several years of drug therapy, followed by slow improvement or remission, but a large number of patients have persistent TD with irreversible symptoms. In the management of TD, the patient's mental status is of primary concern. Currently, no uniformly safe and effective therapies for TD exist, though a variety of therapeutic agents, including some of the atypical neuroleptics, have been reported to treat TD successfully in some patients. Because TD liability is so much lower with novel antipsychotic therapy, all patients who have TD or are at risk for TD, as well as EPS, should be considered candidates for switching to these new drugs. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 18/01/20 alle ore 01:45:05